| Autor: |
Syed Soffian SS; Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia., Mohammed Nawi A; Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia., Hod R; Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia., Ja'afar MH; Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia., Isa ZM; Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia., Chan HK; Clinical Research Center, Sultanah Bahiyah Hospital, Alor Setar 05400, Malaysia., Hassan MRA; Clinical Research Center, Sultanah Bahiyah Hospital, Alor Setar 05400, Malaysia. |
| Abstrakt: |
The Dietary Inflammatory Index (DII) was extensively used to examine the inflammatory potential of diet related to colorectal cancer (CRC). This meta-analysis aimed to update the evidence of the association between the DII and CRC across various culture-specific dietary patterns. Literature search was performed through online databases ( Scopus, Web of Science, PubMed , and EBSCOHost ). Observational studies exploring the association between the DII and CRC, published between 2017 and 2021, were included. The risk ratio (RR) and 95% confidence interval (CI) were separately computed for 12 studies comparing the highest and lowest DII scores and for 3 studies that presented continuous DII scores. A high DII score was associated with a higher risk of CRC (RR:1.16; 95% CI, 1.05-1.27). In the subgroup analysis, significant associations were seen in cohort design (RR: 1.24; 95% CI, 1.06-1.44), those lasting for 10 years or longer (RR: 2.95; 95% CI, 2.47-3.52), and in adjustment factor for physical activity (RR: 1.13; 95% CI, 1.07-1.20). An increase of one point in the DII score elevates the risk of CRC by 1.34 (95% CI: 1.15-1.55) times. The findings call for standardized measurement of the inflammatory potential of diet in future studies to enable the establishment of global guidelines for CRC prevention. |
