| Autor: |
Holmbäck J; Lipidor AB, Svärdvägen 13, SE-182 33 Danderyd, Sweden.; Department of Materials and Environmental Chemistry, Stockholm University, Svante Arrhenius väg 16C, SE-106 91 Stockholm, Sweden., Rinwa V; Lipidor AB, Svärdvägen 13, SE-182 33 Danderyd, Sweden.; Department of Materials and Environmental Chemistry, Stockholm University, Svante Arrhenius väg 16C, SE-106 91 Stockholm, Sweden., Halthur T; CR Competence AB, Naturvetarvägen 14, SE-223 62 Lund, Sweden.; Biofilms-Research Center for Biointerfaces, Department of Biomedical Science, Faculty of Health and Society, Malmö University, Per Albin Hanssons väg 35, SE-214 32 Malmö, Sweden., Rinwa P; Lipidor AB, Svärdvägen 13, SE-182 33 Danderyd, Sweden., Carlsson A; MediGelium AB, Hornsbergs strand 49, SE-112 16 Stockholm, Sweden., Herslöf B; Lipidea AB, Brunbärsvägen 2, SE-114 21 Stockholm, Sweden. |
| Abstrakt: |
A novel formulation technology called AKVANO® has been developed with the aim to provide a tuneable and versatile drug delivery system for topical administration. The vehicle is based on a water-free lipid formulation where selected lipids, mainly phospholipids rich in phosphatidylcholine, are dissolved in a volatile solvent, such as ethanol. With the aim of describing the basic properties of the system, the following physicochemical methods were used: viscometry, dynamic light scattering, NMR diffusometry, and atomic force microscopy. AKVANO formulations are non-viscous, with virtually no or very minute aggregates formed, and when applied to the skin, e.g., by spraying, a thin film consisting of lipid bilayer structures is formed. Standardized in vitro microbiological and irritation tests show that AKVANO formulations meet criteria for antibacterial, antifungal, and antiviral activities and, at the same time, are being investigated as a non-irritant to the skin and eye. The ethanol content in AKVANO facilitates incorporation of many active pharmaceutical ingredients (>80 successfully tested) and the phospholipids seem to act as a solubilizer in the formulation. In vitro skin permeation experiments using Strat-M® membranes have shown that AKVANO formulations can be designed to alter the penetration of active ingredients by changing the lipid composition. |
