| Autor: |
Matz A; Department of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030, USA., Qu L; Department of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030, USA., Karlinsey K; Department of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030, USA., Zhou B; Department of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030, USA.; Institute for Systems Genomics, University of Connecticut, Farmington, CT 06030, USA. |
| Abstrakt: |
Obesity-induced adipose tissue dysfunction is bolstered by chronic, low-grade inflammation and impairs systemic metabolic health. Adipose tissue macrophages (ATMs) perpetuate local inflammation but are crucial to adipose tissue homeostasis, exerting heterogeneous, niche-specific functions. Diversified macrophage actions are shaped through finely regulated factors, including microRNAs, which post-transcriptionally alter macrophage activation. Numerous studies have highlighted microRNAs' importance to immune function and potential as inflammation-modulatory. This review summarizes current knowledge of regulatory networks governed by microRNAs in ATMs in white adipose tissue under obesity stress. |
