MicroRNAs-A Promising Tool for Asthma Diagnosis and Severity Assessment: A Systematic Review.

Autor: Kyyaly MA; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.; The David Hide Asthma and Allergy Research Centre, Isle of Wight PO30 5TG, UK.; Biomedical Science, Faculty of Sport, Health and Social Sciences, Solent University Southampton, Southampton SO14 0YN, UK., Vorobeva EV; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK., Kothalawala DM; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton, Southampton SO16 6YD, UK.; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK., Fong WCG; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.; The David Hide Asthma and Allergy Research Centre, Isle of Wight PO30 5TG, UK.; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton, Southampton SO16 6YD, UK., He P; Optoelectronics Research Centre, University of Southampton, Southampton SO17 1BJ, UK., Sones CL; Optoelectronics Research Centre, University of Southampton, Southampton SO17 1BJ, UK., Al-Zahrani M; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.; Faculty of Applied Medical Sciences, Al-Baha University, Al Baha 65731, Saudi Arabia., Sanchez-Elsner T; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.; The David Hide Asthma and Allergy Research Centre, Isle of Wight PO30 5TG, UK., Arshad SH; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.; The David Hide Asthma and Allergy Research Centre, Isle of Wight PO30 5TG, UK.; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton, Southampton SO16 6YD, UK., Kurukulaaratchy RJ; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.; The David Hide Asthma and Allergy Research Centre, Isle of Wight PO30 5TG, UK.; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton, Southampton SO16 6YD, UK.
Jazyk: angličtina
Zdroj: Journal of personalized medicine [J Pers Med] 2022 Mar 29; Vol. 12 (4). Date of Electronic Publication: 2022 Mar 29.
DOI: 10.3390/jpm12040543
Abstrakt: Micro RNAs (miRNAs) are short, non-coding RNAs (Ribonucleic acids) with regulatory functions that could prove useful as biomarkers for asthma diagnosis and asthma severity-risk stratification. The objective of this systematic review is to identify panels of miRNAs that can be used to support asthma diagnosis and severity-risk assessment. Three databases (Medline, Embase, and SCOPUS) were searched up to 15 September 2020 to identify studies reporting differential expression of specific miRNAs in the tissues of adults and children with asthma. Studies reporting miRNAs associations in animal models that were also studied in humans were included in this review. We identified 75 studies that met our search criteria. Of these, 66 studies reported more than 200 miRNAs that are differentially expressed in asthma patients when compared to non-asthmatic controls. In addition, 16 studies reported 17 miRNAs that are differentially expressed with differences in asthma severity. We were able to construct two panels of miRNAs that are expressed in blood and can serve as core panels to further investigate the practicality and efficiency of using miRNAs as non-invasive biomarkers for asthma diagnosis and severity-risk assessment, respectively.
Databáze: MEDLINE
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