Prospective Real-World Gynaecological Cancer Clinical Registry with Associated Biospecimens: A Collaborative Model to Promote Translational Research between GEICO and the Spanish Biobank Network.

Autor: López-Guerrero JA; Laboratorio de Biología Molecular y Biobanco, Fundación Instituto Valenciano de Oncología, 46009 Valencia, Spain.; Unidad Mixta de Investigación en Cáncer IVO-CIPF, Centro de Investigación Príncipe Felipe (CIPF), 46012 Valencia, Spain.; Departamento de Patología, Facultad de Medicina, Universidad Católica de Valencia 'San Vicente Martir', 46001 Valencia, Spain., Mendiola M; Laboratorio de Patología Molecular y Dianas Terapéuticas, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), 28029 Madrid, Spain.; Centro de Investigación Biomédica en Red de Cáncer, CIBERONC, Instituto de Salud Carlos III, 28029 Madrid, Spain., Pérez-Fidalgo JA; Departamento de Oncología Médica, Hospital Clinico de Valencia, Instituto de Investigación Sanitaria INCLIVA, Universidad de Valencia, CIBERONC, 46010 Valencia, Spain., Romero I; Department of Medical Oncology, Fundación Instituto Valenciano de Oncología, 46009 Valencia, Spain., Torres A; Biobanco del Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain., Recalde D; Biobanco del Sistema de Salud de Aragón, 50009 Zaragoza, Spain., Molina E; Biobanco del Hospital Clínico San Carlos, 28040 Madrid, Spain., Gómez-Raposo C; Department of Medical Oncology, Hospital Universitario Infanta Sofía, 28703 Madrid, Spain., Levin AM; Grupo Español de Investigación en Cáncer de Ovario, 28003 Madrid, Spain., Herrero A; Department of Medical Oncology, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain., Alarcón J; Department of Medical Oncology, Hospital Universitario Son Espases, 07120 Palma, Spain., Esteban C; Department of Medical Oncology, Hospital Virgen de la Salud, 45004 Toledo, Spain., Marquina G; Department of Medical Oncology, Hospital Clínico San Carlos, 28040 Madrid, Spain., Rubio MJ; Department of Medical Oncology, Hospital Universitario Reina Sofía, 14004 Córdoba, Spain., Guerra E; Department of Medical Oncology, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain., Sánchez-Lorenzo L; Department of Medical Oncology, Clínica Universidad de Navarra, 28027 Madrid, Spain., Gálvez-Montosa F; Department of Medical Oncology, Hospital Universitario de Jaén, 23007 Jaén, Spain., de Juan A; Department of Medical Oncology, Hospital Univeristario Marqués de Valdecilla, 39008 Santander, Spain., Churruca C; Department of Medical Oncology, Hospital Universitario Donostia, 20014 Donostia, Spain., Gallego A; Department of Medical Oncology, Hospital Universitario La Paz, 28029 Madrid, Spain., González-Martín A; Department of Medical Oncology, Clínica Universidad de Navarra, 28027 Madrid, Spain.; Programa de Tumores Sólidos, Centro de Investigación de Medicina Aplicada (CIMA), 31008 Pamplona, Spain.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2022 Apr 13; Vol. 14 (8). Date of Electronic Publication: 2022 Apr 13.
DOI: 10.3390/cancers14081965
Abstrakt: Patient registries linked to biorepositories constitute a valuable asset for clinical and translational research in oncology. The Spanish Group of Ovarian Cancer Research (GEICO), in collaboration with the Spanish Biobank Network (RNBB), has developed a multicentre, multistakeholder, prospective virtual clinical registry (VCR) associated with biobanks for the collection of real-world data and biological samples of gynaecological cancer patients. This collaborative project aims to promote research by providing broad access to high-quality clinical data and biospecimens for future research according to the needs of investigators and to increase diagnostic and therapeutic opportunities for gynaecological cancer patients in Spain. The VCR will include the participation of more than 60 Spanish hospitals entering relevant clinical information in harmonised electronic case report forms (eCRFs) in four different cohorts: ovarian, endometrial, cervical, and rare gynaecological cancers (gestational trophoblastic disease). Initial data for the cases included till December 2021 are presented. The model described herein establishes a real-world win-win collaboration between multicentre structures, promoted and supported by GEICO, that will contribute to the success of translational research in gynaecological cancer.
Databáze: MEDLINE
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