| Autor: |
Lipcsey M; Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden., Bergquist M; Department of Medical Sciences, Clinical Physiology, Uppsala University, 75185 Uppsala, Sweden., Sirén R; Department of Medicine, Danderyd Hospital, 18288 Stockholm, Sweden., Larsson A; Department of Medical Sciences, Clinical Chemistry, Uppsala University, 75185 Uppsala, Sweden., Huss F; Burn Center, Department of Plastic and Maxillofacial Surgery, Uppsala University Hospital, 75185 Uppsala, Sweden.; Department of Surgical Sciences, Plastic Surgery, Uppsala University, 75185 Uppsala, Sweden., Pravda J; Inflammatory Disease Research Centre, Therashock LLC, Palm Beach Gardens, FL 33410, USA., Furebring M; Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, 75185 Uppsala, Sweden., Sjölin J; Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, 75185 Uppsala, Sweden., Janols H; Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, 75185 Uppsala, Sweden. |
| Abstrakt: |
Hydrogen peroxide (H2O2) and oxidative stress have been suggested as possible instigators of both the systemic inflammatory response and the increased vascular permeability associated with sepsis and septic shock. We measured H2O2 concentrations in the urine of 82 patients with severe infections, such as sepsis, septic shock, and infections not fulfilling sepsis-3 criteria, in patients with major burn injury with associated systemic inflammation, and healthy subjects. The mean concentrations of H2O2 were found to be lower in patients with severe infections compared to burn injury patients and healthy subjects. Patients with acute kidney injury (AKI), vs. those without AKI, in all diagnostic groups displayed higher concentrations of urine H2O2 (p < 0.001). Likewise, urine concentrations of H2O2 were higher in non-survivors as compared to survivors (p < 0.001) at day 28 in all diagnostic groups, as well as in patients with severe infections and burn injury (p < 0.001 for both). In this cohort, increased H2O2 in urine is thus associated with mortality in patients with sepsis and septic shock as well as in patients with burn injury. |
