| Autor: |
Appelmelk BJ, Verwey-van Vught AM, Maaskant JJ, Schouten WF, Thijs LG, Maclaren DM |
| Jazyk: |
angličtina |
| Zdroj: |
Antonie van Leeuwenhoek [Antonie Van Leeuwenhoek] 1986; Vol. 52 (6), pp. 537-42. |
| DOI: |
10.1007/BF00423414 |
| Abstrakt: |
An antiserum with a high content of antibodies, binding to the Gram-negative lipopolysaccharide core region, was prepared by immunizing rabbits with the rough Escherichia coli mutant J5. This antiserum was capable of protecting mice against lethal challenge doses of E. coli 0 111:B4 in a mouse model where the animals were compromised by means of mucin plus hemoglobin (LD 50 = 10(3) bacteria). However, no protection was observed in a non-compromised mouse model (LD 50 = 10(7) bacteria). This observation might explain why in the past so many discrepant results have been obtained in mouse protection studies with cross-reactive antisera. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink