Surgical versus medical treatment for infective endocarditis in patients on dialysis: a systematic review and meta-analysis.

Autor: Ting SW; Department of Dermatology, New Taipei City Municipal Tucheng Hospital, New Taipei City, ROC., Chen JJ; Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan, ROC., Lee TH; Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan, ROC.; Department of Nephrology, New Taipei City Municipal Tucheng Hospital, New Taipei City, ROC., Kuo G; Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan, ROC.
Jazyk: angličtina
Zdroj: Renal failure [Ren Fail] 2022 Dec; Vol. 44 (1), pp. 706-713.
DOI: 10.1080/0886022X.2022.2064756
Abstrakt: Infective endocarditis (IE) is a serious infection and causes significant morbidity and mortality. However, the benefit of surgery for endocarditis besides antibiotic treatment in dialysis patients remains controversial. We performed a systematic review of studies published between 1960 and February 2022. Meta-analysis was conducted with a random-effects model to explore the in-hospital, 30, 60, 90, 180-d, and 1-year mortality rates in adult dialysis patients with IE. Sensitivity analysis, subgroup analysis, and meta-regression were performed to explore potential sources of heterogeneity. Confidence of evidence was evaluated by the GRADE system. Thirteen studies were included. The pooled odds ratio of in-hospital mortality was 0.62 (95% confidence interval [CI]: 0.30-1.28, p  = .17), with moderate heterogeneity ( I 2 = 62%, p  < .01). Three studies reported 30-d mortality, and the pooled odds ratio for surgery compared with medical treatment was even lower (0.36; 95% CI: 0.22-0.61, p  < .01), with low heterogeneity ( I 2 = 0%, p  = .86). With studies on fewer than 30 patients excluded, the sensitivity analysis revealed a low odds ratio of in-hospital mortality for surgery versus medical treatment (0.52; 95% CI: 0.27-0.99, p  = .047), with moderate heterogeneity ( I 2 = 63%, p  < .01). Subgroup analysis revealed no significant differences between any two comparator subgroups. Based on a very low strength of evidence, compared with medical treatment, surgical treatment for IE in patients on dialysis is not associated with lower in-hospital mortality. When studies on fewer than 30 patients were excluded, surgical treatment was associated with better survival.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje