Relapsing High-Grade Glioma from Peritumoral Zone: Critical Review of Radiotherapy Treatment Options.

Autor: Lo Greco MC; Department Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali, Università di Messina, 98100 Messina, Italy., Milazzotto R; U.O. Radioterapia Oncologica, A.O.U. Policlinico 'G. Rodolico-San Marco' Catania, Via Santa Sofia 78, 95123 Catania, Italy., Liardo RLE; U.O. Radioterapia Oncologica, A.O.U. Policlinico 'G. Rodolico-San Marco' Catania, Via Santa Sofia 78, 95123 Catania, Italy., Acquaviva G; U.O.C. Radioterapia A.O.E. Cannizzaro di Catania, 95100 Catania, Italy., La Rocca M; Department Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali, Università di Messina, 98100 Messina, Italy., Altieri R; Division of Neurosurgery, Department of Neurosciences, Policlinico 'G. Rodolico-San Marco', University Hospital, 95121 Catania, Italy.; Multidisciplinary Research Center on Brain Tumors Diagnosis and Treatment, University of Catania, 95123 Catania, Italy., Certo F; Division of Neurosurgery, Department of Neurosciences, Policlinico 'G. Rodolico-San Marco', University Hospital, 95121 Catania, Italy.; Multidisciplinary Research Center on Brain Tumors Diagnosis and Treatment, University of Catania, 95123 Catania, Italy., Barbagallo GM; Division of Neurosurgery, Department of Neurosciences, Policlinico 'G. Rodolico-San Marco', University Hospital, 95121 Catania, Italy.; Multidisciplinary Research Center on Brain Tumors Diagnosis and Treatment, University of Catania, 95123 Catania, Italy., Basile A; U.O. Radiologia I, A.O.U. Policlinico 'G. Rodolico-San Marco', Via Santa Sofia 78, 95123 Catania, Italy.; Department Scienze Mediche, Chirurgiche e Tecnologie Avanzate 'G.F. Ingrassia', Università di Catania, 95125 Catania, Italy., Foti PV; U.O. Radiologia I, A.O.U. Policlinico 'G. Rodolico-San Marco', Via Santa Sofia 78, 95123 Catania, Italy.; Department Scienze Mediche, Chirurgiche e Tecnologie Avanzate 'G.F. Ingrassia', Università di Catania, 95125 Catania, Italy., Palmucci S; U.O. Radiologia I, A.O.U. Policlinico 'G. Rodolico-San Marco', Via Santa Sofia 78, 95123 Catania, Italy.; Department Scienze Mediche, Chirurgiche e Tecnologie Avanzate 'G.F. Ingrassia', Università di Catania, 95125 Catania, Italy., Pergolizzi S; Department Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali, Università di Messina, 98100 Messina, Italy., Pontoriero A; Department Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali, Università di Messina, 98100 Messina, Italy., Spatola C; U.O. Radioterapia Oncologica, A.O.U. Policlinico 'G. Rodolico-San Marco' Catania, Via Santa Sofia 78, 95123 Catania, Italy.; Multidisciplinary Research Center on Brain Tumors Diagnosis and Treatment, University of Catania, 95123 Catania, Italy.; Department Scienze Mediche, Chirurgiche e Tecnologie Avanzate 'G.F. Ingrassia', Università di Catania, 95125 Catania, Italy.
Jazyk: angličtina
Zdroj: Brain sciences [Brain Sci] 2022 Mar 22; Vol. 12 (4). Date of Electronic Publication: 2022 Mar 22.
DOI: 10.3390/brainsci12040416
Abstrakt: Glioblastoma (GBM) is the most common and aggressive brain tumor in adults, with a median survival of about 15 months. After the prior treatment, GBM tends to relapse within the high dose radiation field, defined as the peritumoral brain zone (PTZ), needing a second treatment. In the present review, the primary role of ionizing radiation in recurrent GBM is discussed, and the current literature knowledge about the different radiation modalities, doses and fractionation options at our disposal is summarized. Therefore, the focus is on the necessity of tailoring the treatment approach to every single patient and using radiomics and PET/MRI imaging to have a relatively good outcome and avoid severe toxicity. The use of charged particle therapy and radiosensitizers to overcome GBM radioresistance is considered, even if further studies are necessary to evaluate the effectiveness in the setting of reirradiation.
Databáze: MEDLINE
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