Postnatal baicalin ameliorates behavioral and neurochemical alterations in valproic acid-induced rodent model of autism: The possible implication of sirtuin-1/mitofusin-2/ Bcl-2 pathway.

Autor: Elesawy RO; Pharmacology Department, Faculty of Medicine, Tanta University, Tanta, Egypt., El-Deeb OS; Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt., Eltokhy AK; Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt., Arakeep HM; Anatomy and Embryology Department, Faculty of Medicine, Tanta University, Tanta, Egypt., Ali DA; Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt., Elkholy SS; Physiology Department, Faculty of Medicine, Kafrelsheikh University, Kafr El-Shaikh, Egypt., Kabel AM; Pharmacology Department, Faculty of Medicine, Tanta University, Tanta, Egypt. Electronic address: ahmed.kabal@med.tanta.edu.eg.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Jun; Vol. 150, pp. 112960. Date of Electronic Publication: 2022 Apr 18.
DOI: 10.1016/j.biopha.2022.112960
Abstrakt: Autism spectrum disorder (ASD) is characterized by pervasive impairments in social communication along with repetitive or stereotyped behaviors. Although its distinctive etiology isn`t completely understood, genetic and environmental risk factors were incriminated. Being a flavonoid of high biomedical value, baicalin was recently verified as an emerging medicinal herb with numerous pharmacological activities. The objective of this study was to investigate the feasible effects of baicalin on valproic acid (VPA)-induced autism regarding its potential mitochondrial modulatory, antioxidant, and antiapoptotic effects. The present study was performed using a rodent model of autism by exposing rat fetuses to VPA on the 12.5th day of gestation. Ten male Wistar rats that were born from control pregnant females were considered as group I (control group). Twenty male Wistar rats that were born from prenatal VPA- treated females were further divided into two groups: Group II (VPA- induced ASD) and group III (VPA + Baicalin). Postnatal baicalin promoted postnatal growth and maturation. In addition, it improved motor development and ameliorated repetitive behavior as well as social deficits in prenatally exposed VPA rats. Moreover, baicalin enhanced neuronal mitochondrial functions as evidenced by elevation of mitochondrial adenosine triphosphate (ATP) level and promotion of mitofusin-2 expression. Furthermore, baicalin elevated sirtuin-1 (SIRT1) level in VPA rats' brain tissues and restored the antioxidant defense mechanisms. Besides, it abrogated the neuronal histopathological changes in the brain tissues. Based on the data herein, baicalin may provide a promising pre-clinical therapeutic line in ASD as a mitochondrial function modulator, antioxidant and anti-apoptotic agent.
(Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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