Dectin-1b activation by arabinoxylans induces trained immunity in human monocyte-derived macrophages.

Autor: Moerings BGJ; Wageningen Food and Biobased Research, Wageningen University & Research, Wageningen, the Netherlands; Nutritional Biology, Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands., van Bergenhenegouwen J; Danone Nutricia Research, Utrecht, the Netherlands., Furber M; Danone Nutricia Research, Utrecht, the Netherlands., Abbring S; Wageningen Food and Biobased Research, Wageningen University & Research, Wageningen, the Netherlands; Nutritional Biology, Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands., Schols HA; Laboratory of Food Chemistry, Wageningen University & Research, Wageningen, the Netherlands., Witkamp RF; Nutritional Biology, Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands., Govers C; Cell Biology and Immunology Group, Wageningen University & Research, Wageningen, the Netherlands., Mes JJ; Wageningen Food and Biobased Research, Wageningen University & Research, Wageningen, the Netherlands. Electronic address: jurriaan.mes@wur.nl.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2022 Jun 01; Vol. 209 (Pt A), pp. 942-950. Date of Electronic Publication: 2022 Apr 18.
DOI: 10.1016/j.ijbiomac.2022.04.071
Abstrakt: Arabinoxylans of various structures and sources have shown to possess the ability to induce a range of immune responses in different cell types in vitro and in vivo. Although the underlying mechanisms remain to be fully established, several studies point towards the involvement of activation of pattern recognition receptors (PRRs). Activation of specific PRRs (i.e., Dectin-1 and CR3) has also been shown to play a key role in the induction of a non-specific memory response in innate immune cells, termed 'trained innate immunity'. In the current study, we assessed whether arabinoxylans are also able to induce trained innate immunity. To this end, a range of arabinoxylan preparations from different sources were tested for their physicochemical properties and their capacity to induce innate immune training and resilience. In human macrophages, rice and wheat-derived arabinoxylan preparations induced training and/or resilience effects, the extent depending on fiber particle size and solubility. Using a Dectin-1 antagonist or a CR3 antibody, it was demonstrated that arabinoxylan-induced trained immunity in macrophages is mainly dependent on Dectin-1b. These findings build on previous observations showing the immunomodulatory potential of arabinoxylans as biological response modifiers and open up promising avenues for their use as health promoting ingredients.
(Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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