| Autor: |
Márkus B; 1 Department of Family Medicine, Semmelweis University, Budapest, Hungary., Temesszentandrási G; 2 Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary., Vörös K; 1 Department of Family Medicine, Semmelweis University, Budapest, Hungary., Jakab L; 2 Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary., Fekete B; 2 Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary., Farkas H; 2 Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary.; 3 National Angioedema Center, Semmelweis University, Budapest, Hungary., Prohászka Z; 2 Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary.; 3 National Angioedema Center, Semmelweis University, Budapest, Hungary., Masszi T; 2 Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary., Kalabay L; 1 Department of Family Medicine, Semmelweis University, Budapest, Hungary.; 2 Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary. |
| Abstrakt: |
Helicobacter pylori is a common pathogen causing gastric inflammation and malignancy. Fetuin-A is a multifunctional protein that is involved in the regulation of calcification, insulin resistance and inflammation. Reports on serum levels of fetuin-A in acute H. pylori infection are contradictory. We intended to see whether H. pylori post-infection status has a long-term effect on serum fetuin-A levels in a well-characterized series of systemic lupus erythematosus cases. In this cross-sectional study 117 patients with systemic lupus erythematosus were enrolled. Helicobacter infection status and serum fetuin-A concentration were determined by ELISA and radial immunodiffusion, respectively. H. pylori positive patients had higher serum fetuin-A concentration than negative ones: 517 (456-603) vs. 476 (408-544) mg L-1, median (25-75% percentiles), P = 0.020. No other parameters differed between these groups. During univariate regression analysis fetuin-A levels were associated with Erythrocyte sedimentation rate (ESR), White blood cell count (WBC), C-reactive protein (CRP), serum total protein, albumin, and the SLEDAI index at the time of diagnosis but only serum albumin remained a significant determinant in multivariate regression study. |
