Thiamine alleviates cognitive impairment and epileptogenesis by relieving brain inflammation in PTZ-induced kindling rat model.
| Autor: | Karabulut S; Department of Medical Services and Techniques, Vocational School of Health Services, Sivas Cumhuriyet University, Sivas, Turkey., Filiz AK; Department of Medical Physiology, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey., Akkaya R; Department of Biophysics, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Neurological research [Neurol Res] 2022 Oct; Vol. 44 (10), pp. 902-909. Date of Electronic Publication: 2022 Apr 21. |
| DOI: | 10.1080/01616412.2022.2066785 |
| Abstrakt: | Objective: Epileptogenesis, the process by which the brain becomes epileptic, is related to neuroinflammation, hyperexcitability cognitive deficits. Evidence suggests that improving brain inflammation can inhibit the epileptogenesis process and help the emergence of new drugs for the treatment of epilepsy. Therefore, the PTZ kindling model of epilepsy was utilized to assess the neuroprotective role of thiamine in epileptogenesis. Methods: Male rats were exposed to PTZ-induced kindling and pretreated with low thiamine (25 mg/kg) or high thiamine (50 mg/kg). Cyclooxygenase (COX-1 and COX-2), interleukin 1-beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and nuclear factor-κB (NF-κB) concentrations in the brain were analyzed using biochemical assays. Cognitive function was evaluated using the passive avoidance test. Results: Thiamine ameliorated epileptogenesis and enhanced the rats' performance in the passive avoidance test. Also, thiamine significantly decreased the level of neuroinflammatory mediators in the brain induced by PTZ. Conclusion: These results provide evidence that thiamine alleviates PTZ-induced neuroinflammation and cognitive impairments. |
| Databáze: | MEDLINE |
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