ACTH vs steroids for the treatment of acute gout in hospitalized patients: a randomized, open label, comparative study.

Autor: Daoussis D; Department of Rheumatology, Patras University Hospital, University of Patras Medical School, Patras, Greece. jimdaoussis@hotmail.com., Kordas P; North Sector Health Center, Patras, Greece., Varelas G; Data and Media Lab, Department of Electrical and Computer Engineering, University of Peloponnese, Tripoli, Greece., Michalaki M; Department of Endocrinology, Patras University Hospital, University of Patras Medical School, Patras, Greece., Onoufriou A; Department of Microbiology, Patras University Hospital, University of Patras Medical School, Patras, Greece., Mamali I; Department of Endocrinology, Patras University Hospital, University of Patras Medical School, Patras, Greece., Iliopoulos G; Department of Rheumatology, Patras University Hospital, University of Patras Medical School, Patras, Greece., Melissaropoulos K; Department of Rheumatology, Agios Andreas Hospital, Patras, Greece., Ntelis K; Department of Rheumatology, Agios Andreas Hospital, Patras, Greece., Velissaris D; Department of Internal Medicine, Patras University Hospital, University of Patras Medical School, Patras, Greece., Tzimas G; Data and Media Lab, Department of Electrical and Computer Engineering, University of Peloponnese, Tripoli, Greece., Georgiou P; Department of Rheumatology, Agios Andreas Hospital, Patras, Greece., Vamvakopoulou S; Department of Microbiology, Patras University Hospital, University of Patras Medical School, Patras, Greece., Paliogianni F; Department of Microbiology, Patras University Hospital, University of Patras Medical School, Patras, Greece., Andonopoulos AP; Professor Emeritus, University of Patras, Patras, Greece., Georgopoulos N; Department of Endocrinology, Patras University Hospital, University of Patras Medical School, Patras, Greece.
Jazyk: angličtina
Zdroj: Rheumatology international [Rheumatol Int] 2022 Jun; Vol. 42 (6), pp. 949-958. Date of Electronic Publication: 2022 Apr 21.
DOI: 10.1007/s00296-022-05128-x
Abstrakt: The management of acute gout in the hospital setting may be challenging since most patients are elderly with multiple unstable comorbidities. However, there are no prospective clinical trials for hospitalized patients with gout to guide optimal management. Evidence indicates that steroids or adrenocorticotropic hormone (ACTH) may be effective and safe therapeutic options for these patients. This study aimed at directly comparing the efficacy and safety of ACTH vs betamethasone for the treatment of gout in hospitalized patients. This is the first prospective clinical trial for hospitalized patients with gout. We designed a randomized, open label study to assess the efficacy and safety of a single intramuscular injection of either ACTH or betamethasone in hospitalized patients with acute gout. Primary efficacy endpoints were the change in intensity of pain as recorded using a Visual Analogue Scale (VAS) at baseline compared to 24 h (ΔVAS24h), and 48 h. Moreover, we assessed safety and effects on the hypothalamic-pituitary-adrenal (HPA) axis, glucose and lipid homeostasis, bone metabolism, electrolytes and renal function. 38 patients were recruited. Both treatments were highly effective. The mean ± SE ΔVAS24h and ΔVAS48h for ACTH was 4.48 ± 0.29 and 5.58 ± 0.26, respectively. The mean ± SE ΔVAS24h and ΔVAS48h for betamethasone was 4.67 ± 0.32 and 5.67 ± 0.28, respectively. Direct comparison between the two groups at 24 h and 48 h did not show statistically significant differences. Both treatments were well tolerated and safe. The effects on all metabolic parameters were mostly minimal and transient for both treatments. However, ACTH may affect less the HPA axis and bone metabolism compared to betamethasone, thus leading to the conclusion that. ACTH and betamethasone are effective and safe for the management of acute gout in hospitalized patients but that ACTH may associate with less disturbance of the HPA axis and bone metabolism. Our data support the use of both drugs as first line treatments for hospitalized patients with gout.Clinical trial registration: ClinicalTrials.gov NCT04306653.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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