[Analysis of Chemotherapy-Induced Nausea and Vomiting during Chemotherapy for Gastric Cancer].

Autor:	Kawada J; Dept. of Surgery, Yao Municipal Hospital., Mizuno M, Fukada A, Nakano M, Murotani M, Nagano S, Yoneda N, Kidogami S, Mokutani Y, Kishimoto T, Hashimoto Y, Hirose H, Yoshioka S, Tamura S, Sasaki Y
Jazyk:	japonština
Zdroj:	Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2022 Apr; Vol. 49 (4), pp. 462-464.
Abstrakt:	Background: Chemotherapy-induced nausea and vomiting(CINV)are typical side effects caused by chemotherapy. We analyzed CINV during first-line chemotherapy for gastric cancer. Materials and Method: Thirty-one patients who received first-line chemotherapy for gastric cancer were retrospectively assessed for CINV. Results: The median age was 70 years, and the gender(male/female)was 23/8 cases. NK1 receptor antagonist, 5-HT3 receptor antagonist, and dexamethasone were used as antiemetic agents in 29 patients(94%). Sixteen patients(52%)had Grade 1 or higher nausea, and 6 patients (19%)had Grade 1 or higher vomiting, and complete control of nausea and vomiting was achieved in 21 patients(68%). Nausea was significantly more frequent in patients with liver metastasis(p=0.0008), but there was no significant difference in vomiting(p=1.0000). There was no significant difference in the occurrence of CINV between chemotherapy regimens or combination of olanzapine. Conclusion: During first-line chemotherapy for gastric cancer, 3 antiemetic agents were used in 94% of cases, and the complete control rate of CINV was 67.8%.
Databáze:	MEDLINE
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