Peripheral Arterial Tonometry (EndoPAT)-measured Endothelial Dysfunction in Migraine with Aura children.

Autor:	Bonuccelli A; Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa. al.bonuccelli@gmail.com., Sciarrotta C; Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa. claudiasciarrotta@gmail.com., Esposito MG; Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa. maryagrazya@gmail.com., Bianchi V; Pediatric Diabetology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa. bianchi.vanessa@alice.it., Miccoli M; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. mario.miccoli@med.unipi.it., Striano P; Pediatric Neurology Unit, Dinogmi, Giannina Gaslini's. Istitute, University of Genoa. strianop@gmail.com., D'angelo R; Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa. riccardodangelodietista@gmail.com., Valiani M; Pediatric Diabetology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa. margheritavaliani@gmail.com., Randazzo E; Pediatric Diabetology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Italy. emioli.randazzo@gmail.com., Foiadelli T; Pediatric Clinic, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy. t.foiadelli@smatteo.pv.it., Peroni D; Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Italy. diego.peroni@unipi.it., Federico G; Pediatric Diabetology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Italy. g.federico@med.unipi.it., Orsini A; Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Italy. aorsini.md@gmail.com.
Jazyk:	angličtina
Zdroj:	Acta bio-medica : Atenei Parmensis [Acta Biomed] 2022 Mar 21; Vol. 92 (S4), pp. e2021345. Date of Electronic Publication: 2022 Mar 21.
DOI:	10.23750/abm.v92iS4.12674
Abstrakt:	Background: The association between Migraine with Aura (MA) and vascular disease has been previously reported. We investigated whether pre-clinical vascular alterations, such as Endothelial Dysfunction, are already present in children and adolescents with Migraine with Aura. Methods: We retrospectively enrolled 27 patients having Migraine with Aura, aged9 -18 years, and 31 age matched healthy control subjects to evaluateEndothelial Function by Peripheral Arterial Tonometry. This technique measures finger pulse wave amplitude, before and during reactive hyperaemia, and calculates the Augmentation Index (AI) and the Reactive Hyperaemia Index (RHI). We also set-up an Aura Severity Scale to assess disease severity and its relationship with AI and RHI alterations. Results: Also if the case-control study resulted only partially as significant, we found there is an inversely proportional relationship between the severity of the migraine measured with Aura Severity Scale and the values of the endoscore (a significantly reduced levels of AI (p-value <0,03) and a marginal reduction of RHI levels (p-value <0,07). Conclusion: Further studies should explore the impact of pre-clinical vascular alterations in children and adolescents with Migraine with Aura.
Databáze:	MEDLINE
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