Evidence for postnatal neurogenesis in the human amygdala.

Autor: Roeder SS; Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany., Burkardt P; Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany., Rost F; Center for Regenerative Therapies (CRTD), TU Dresden, Dresden, Germany.; Max Planck Institute for the Physics of Complex Systems, Dresden, Germany.; Center for Information Services and High Performance Computing (ZIH), TU Dresden, Dresden, Germany.; Center for Molecular and Cellular Bioengineering, DRESDEN-concept Genome Center, TU Dresden, Dresden, Germany., Rode J; Center for Information Services and High Performance Computing (ZIH), TU Dresden, Dresden, Germany., Brusch L; Center for Information Services and High Performance Computing (ZIH), TU Dresden, Dresden, Germany., Coras R; Department of Neuropathology, University of Erlangen-Nuremberg, Erlangen, Germany., Englund E; Department of Neuropathology, University of Lund, Lund, Sweden., Håkansson K; Tandem Laboratory, Uppsala University, Uppsala, Sweden.; Department of Physics and Astronomy, Uppsala University, Uppsala, Sweden., Possnert G; Tandem Laboratory, Uppsala University, Uppsala, Sweden., Salehpour M; Department of Physics and Astronomy, Uppsala University, Uppsala, Sweden., Primetzhofer D; Tandem Laboratory, Uppsala University, Uppsala, Sweden.; Department of Physics and Astronomy, Uppsala University, Uppsala, Sweden., Csiba L; Department of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.; MTA-DE Cerebrovascular and Neurodegenerative Research Group, Debrecen, Hungary., Molnár S; Department of Pathology, University of Debrecen, Debrecen, Hungary., Méhes G; Department of Pathology, University of Debrecen, Debrecen, Hungary., Tonchev AB; Departments of Anatomy, Cell Biology and Stem Cell Biology, Medical University Varna, Varna, Bulgaria., Schwab S; Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany., Bergmann O; Center for Regenerative Therapies (CRTD), TU Dresden, Dresden, Germany.; Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden., Huttner HB; Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany. Hagen.Huttner@neuro.med.uni-giessen.de.; Department of Neurology, Justus Liebig University Giessen, Giessen, Germany. Hagen.Huttner@neuro.med.uni-giessen.de.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2022 Apr 19; Vol. 5 (1), pp. 366. Date of Electronic Publication: 2022 Apr 19.
DOI: 10.1038/s42003-022-03299-8
Abstrakt: The human amygdala is involved in processing of memory, decision-making, and emotional responses. Previous studies suggested that the amygdala may represent a neurogenic niche in mammals. By combining two distinct methodological approaches, lipofuscin quantification and 14 C-based retrospective birth dating of neurons, along with mathematical modelling, we here explored whether postnatal neurogenesis exists in the human amygdala. We investigated post-mortem samples of twelve neurologically healthy subjects. The average rate of lipofuscin-negative neurons was 3.4%, representing a substantial proportion of cells substantially younger than the individual. Mass spectrometry analysis of genomic 14 C-concentrations in amygdala neurons compared with atmospheric 14 C-levels provided evidence for postnatal neuronal exchange. Mathematical modelling identified a best-fitting scenario comprising of a quiescent and a renewing neuronal population with an overall renewal rate of >2.7% per year. In conclusion, we provide evidence for postnatal neurogenesis in the human amygdala with cell turnover rates comparable to the hippocampus.
(© 2022. The Author(s).)
Databáze: MEDLINE
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