DOPAMAP, high-resolution images of dopamine 1 and 2 receptor expression in developing and adult mouse brains.

Autor: Bjerke IE; Neural Systems Laboratory, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway., Cullity ER; Mental Health Theme, Florey Institute of Neuroscience and Mental Health, Melbourne, Australia., Kjelsberg K; Neural Systems Laboratory, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway., Charan KM; ISN Psychology, Institute for Social Neuroscience, Ivanhoe, Australia., Leergaard TB; Neural Systems Laboratory, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway., Kim JH; Mental Health Theme, Florey Institute of Neuroscience and Mental Health, Melbourne, Australia. drjeehyunkim@gmail.com.; IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, Australia. drjeehyunkim@gmail.com.
Jazyk: angličtina
Zdroj: Scientific data [Sci Data] 2022 Apr 19; Vol. 9 (1), pp. 175. Date of Electronic Publication: 2022 Apr 19.
DOI: 10.1038/s41597-022-01268-8
Abstrakt: The dopaminergic system undergoes major reorganization during development, a period especially vulnerable to mental disorders. Forebrain neurons expressing dopamine 1 and 2 receptors (D1R and D2R, respectively) play a key role in this system. However, neuroanatomical information about the typical development of these neurons is sparse and scattered across publications investigating one or a few brain regions. We here present a public online collection of microscopic images of immunohistochemically stained serial sections from male and female mice at five stages of development (postnatal day 17 (P17), P25, P35, P49, and adult), showing the distribution of D1R and D2R expressing neurons across the forebrain. All images from adult brains are registered to the Allen Mouse brain Common Coordinate Framework, while images from P17-P35 age groups are registered to spatially modified atlas versions matching the morphology of young brains. This online resource provides microscopic visualization of the developing dopaminergic system in mice, which is suitable as a benchmark reference for performing new experiments and building computational models of the brain.
(© 2022. The Author(s).)
Databáze: MEDLINE
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