Rate of thromboembolic and bleeding events in patients undergoing concomitant aortic valve surgery with left ventricular assist device implantation.
Autor: | Yalcin YC; Department of Cardiology, University Medical Center Rotterdam, Thorax Center, Rotterdam, the Netherlands; Department of Cardiothoracic Surgery, Erasmus MC, University Medical Center Rotterdam, Thorax Center, Rotterdam, the Netherlands., Veenis JF; Department of Cardiology, University Medical Center Rotterdam, Thorax Center, Rotterdam, the Netherlands., Brugts JJ; Department of Cardiology, University Medical Center Rotterdam, Thorax Center, Rotterdam, the Netherlands., Antonides CFJ; Department of Cardiothoracic Surgery, Erasmus MC, University Medical Center Rotterdam, Thorax Center, Rotterdam, the Netherlands., Veen KM; Department of Cardiothoracic Surgery, Erasmus MC, University Medical Center Rotterdam, Thorax Center, Rotterdam, the Netherlands., Muslem R; Department of Cardiothoracic Surgery, Erasmus MC, University Medical Center Rotterdam, Thorax Center, Rotterdam, the Netherlands., Bekkers JA; Department of Cardiothoracic Surgery, Erasmus MC, University Medical Center Rotterdam, Thorax Center, Rotterdam, the Netherlands., Gustafsson F; Department of Cardiology, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark., Tedford RJ; Department of medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC, USA., Bogers AJJC; Department of Cardiothoracic Surgery, Erasmus MC, University Medical Center Rotterdam, Thorax Center, Rotterdam, the Netherlands., Caliskan K; Department of Cardiology, University Medical Center Rotterdam, Thorax Center, Rotterdam, the Netherlands. Electronic address: k.caliskan@erasmusmc.nl. |
---|---|
Jazyk: | angličtina |
Zdroj: | International journal of cardiology [Int J Cardiol] 2022 Jul 15; Vol. 359, pp. 39-45. Date of Electronic Publication: 2022 Apr 18. |
DOI: | 10.1016/j.ijcard.2022.04.041 |
Abstrakt: | Background: Significant aortic regurgitation at the time of left ventricular assist device (LVAD) implantation, requires concomitant aortic valve (AoV) replacement or repair. However, the impact of concomitant AoV surgery on morbidity remains unknown. Therefore, our aim is to determine the impact of concomitant AoV surgery on thromboembolic and bleeding events. Methods: A retrospective IMACS registry study, including patients implanted from 2013 until September 2017. Differences between different concomitant AoV surgery modalities were analyzed. Results: In total, 785 (5.1%) out of 15.267 patients (median age 58 IQR 49-66 years, 79% male) underwent concomitant AoV surgery (median age 63 IQR 54-69 years, 84% male); 386 (49%) patients received biological prostheses, 71 (9%) mechanical prostheses and 328 (42%) AoV repairs. In total, 54 (8%) patients with AoV surgery experienced a thromboembolic event and 1016 (9%) patients with no AoV surgery. Furthermore, concomitant AoV surgery was associated with an increased rate of all and nonsurgical bleedings. Following a multivariable Cox regression, concomitant AoV surgery remained an independent predictor for bleeding events. Conclusions: In LVAD patients undergoing concomitant AoV surgery, thromboembolic event rates were not higher, however both all and nonsurgical bleeding event rates were higher. (Copyright © 2022. Published by Elsevier B.V.) |
Databáze: | MEDLINE |
Externí odkaz: |