| Autor: |
Buysse AM; Research and Development, Corteva Agriscience, 9330 Zionsville Road, Indianapolis, Indiana 46268, United States., Herbert J; Research and Development, Corteva Agriscience, 9330 Zionsville Road, Indianapolis, Indiana 46268, United States., Lambert WT; Research and Development, Corteva Agriscience, 9330 Zionsville Road, Indianapolis, Indiana 46268, United States., Wessels FJ; Research and Development, Corteva Agriscience, 9330 Zionsville Road, Indianapolis, Indiana 46268, United States. |
| Abstrakt: |
The insecticidal activity of pyridine compounds substituted at the 4-position with lipophilic groups has been reported in recent agrochemical patent applications. Encouraged by these reports, 4-pyridyl dihydroisobenzofuran(one)s were designed to test scaffold-hopping hypotheses with the goal of discovering new insecticidally active areas of chemistry. A series of 4-pyridyl dihydroisobenzofuran(one)s were synthesized, and their activity against key sap-feeding insect pests (silverleaf whitefly, Bemisia tabaci ; green peach aphid, Myzus persicae ) was assessed. Many of these compounds showed strong activity (comparable to commercial standards) against B. tabaci and were also active against M. persicae , although activity on this pest was somewhat weaker. Investigative biology studies indicated that these compounds were active on early life stages of B. tabaci but lacked significant activity on adults. |
