Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI.

Autor:	Basquiera AL; Hospital Privado Universitario de Córdoba, Córdoba, Argentina; Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. Electronic address: ana.basquiera@hospitalprivado.com.ar., Odstrcil Bobillo MS; Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Peroni ML; Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Sanchez Thomas D; Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Vitriu A; Instituto Alexander Fleming, Buenos Aires, Argentina., Berro M; Hospital Universitario Austral, Pilar, Buenos Aires, Argentina., Rosales Ostriz B; Hospital Nacional de Clínicas José de San Martín, Buenos Aires, Argentina., Milovic V; Hospital Alemán, Buenos Aires, Argentina., Martinez Rolón J; FUNDALEU, Buenos Aires, Argentina., Jaimovich G; Fundación Favaloro, Buenos Aires, Argentina., Hansen Krogh D; Instituto Nacional Central Único Coordinador de Ablación e Implante (INCUCAI), Buenos Aires, Argentina., Tagliafichi V; Instituto Nacional Central Único Coordinador de Ablación e Implante (INCUCAI), Buenos Aires, Argentina., Bisigniano L; Instituto Nacional Central Único Coordinador de Ablación e Implante (INCUCAI), Buenos Aires, Argentina., Arbelbide JA; Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Giunta DH; Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Jazyk:	angličtina
Zdroj:	Hematology, transfusion and cell therapy [Hematol Transfus Cell Ther] 2023 Apr-Jun; Vol. 45 (2), pp. 224-234. Date of Electronic Publication: 2022 Apr 11.
DOI:	10.1016/j.htct.2022.02.008
Abstrakt:	Introduction: Hematopoietic stem cell transplantation is the only curative treatment for many disorders and international data shows a growing trend. Method: We aimed to evaluate the temporal trends in HSCT transplant rates in Argentina. A time-series analysis was performed for the period 2009 to 2018 using the national database from the National Central Coordinating Institute for Ablations and Implants. Crude and standardized transplant rates were calculated. A permutation joinpoint regression model analysis was used to identify significant changes over time. Results: Altogether, 8,474 transplants were reported to INCUCAI by 28 centers (autologous 67.5%); the main indication was multiple myeloma (30%). The WHO age-sex standardized HSCT rates for the entire country were 153.3 HSCT/10 million inhabitants (95% CI 141.7-165.8) in 2009 and 260.1 HSCT/10 million inhabitants (95% CI 245.5-275.5) in 2018. There was a large gap in HSCT rates among the states and regions. The transplant rate was higher for autologous transplants throughout the years. Within the allogeneic group, the related donor transplant rate was higher than the unrelated donor transplant rate. The joinpoint regression analysis of HSCT rates for the whole country over time showed an observed annual percentage change of 6.3% (95% CI 5.4-7.3; p < 0.01). No changes were observed for unrelated donors during the study period. Conclusions: Age-sex standardized HSCT rates in Argentina are increasing, mainly due to autologous and family donor allogeneic transplants. A wide variation across the country was found, demonstrating differences in the access to transplantation among Argentine regions. Competing Interests: Conflicts of interest The author declares no conflicts of interest. (Copyright © 2022 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu