Mesenchymal stromal/stem cell therapy for radiation-induced salivary gland hypofunction in animal models: a protocol for a systematic review and meta-analysis.

Autor: Jansson PM; Department of Otolaryngology and Audiology, Head and Neck Surgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; The Royal Library, Library of Copenhagen, University of Copenhagen, Copenhagen, Denmark., Lynggaard CD; Department of Otolaryngology and Audiology, Head and Neck Surgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. clynggaard@dadlnet.dk.; The Royal Library, Library of Copenhagen, University of Copenhagen, Copenhagen, Denmark. clynggaard@dadlnet.dk.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. clynggaard@dadlnet.dk., Carlander AF; Department of Otolaryngology and Audiology, Head and Neck Surgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Jensen SB; Deparment of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark., Follin B; Cardiology Stem Cell Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Hoeeg C; Cardiology Stem Cell Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Kousholt BS; Aarhus University Group for Understanding Systematic Reviews and Meta-analyses in Translational Preclinical Science, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Larsen RT; Department of Occupational Therapy and Physiotherapy, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Grønhøj C; Department of Otolaryngology and Audiology, Head and Neck Surgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Jakobsen KK; Department of Otolaryngology and Audiology, Head and Neck Surgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Rimborg S; The Royal Library, Library of Copenhagen, University of Copenhagen, Copenhagen, Denmark., Fischer-Nielsen A; Department of Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Menon JML; Systematic Review Center for Laboratory animal Experimentation (SYRCLE), Department for Health Evidence, Radboud University Medical Center, Nimegen, the Netherlands., von Buchwald C; Department of Otolaryngology and Audiology, Head and Neck Surgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Systematic reviews [Syst Rev] 2022 Apr 18; Vol. 11 (1), pp. 72. Date of Electronic Publication: 2022 Apr 18.
DOI: 10.1186/s13643-022-01943-2
Abstrakt: Background: Salivary gland (SG) hypofunction (objectively reduced saliva flow rate) and xerostomia (subjective sensation of dry mouth) are common and burdensome side effects of radiotherapy to the head and neck region. Currently, only sparse symptomatic treatment is available to ease the discomfort of xerostomia. The objective of this study is to assess the effect of mesenchymal stem cell (MSC) therapy on SG function after radiation-induced injury.
Methods: This systematic review will include animal intervention studies assessing efficacy and safety of MSCs in treating radiation-induced SG hypofunction. The primary outcome is the effect of MSC administration on salivary flow rates (SFR), by comparing treated groups to control groups when available. Secondary outcomes are morphological and immunohistochemical effects as well as safety of MSC treatment. Electronic searches in MEDLINE (PubMed) and Embase databases will be constructed and validated according to the peer review of electronic search strategies (PRESS) and assessed by two independent researchers. Data from eligible studies will be extracted, pooled, and analyzed using random-effects models. Risk of bias will be evaluated with the Systematic Review Centre for Laboratory animal Experimentation (SYRCLE) risk of bias tool.
Discussion: Thus far, critical appraisal of MSC therapy as an effective treatment for SG hypofunction caused solely by radiation injury has not been conducted. A summary of the existing literature on preclinical studies concerning this issue can provide valuable information about effectiveness, mode of action, and safety, allowing further optimization of preclinical and clinical trials.
Systematic Review Registration: PROSPERO CRD42021227336.
(© 2022. The Author(s).)
Databáze: MEDLINE
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