| Autor: |
Basu K; Department of Pathology and Dermatology, Institute of Postgraduate Medical Education and Research, Kolkata, India; kbasughosh@gmail.com., Karmakar S; Department of Pathology and Dermatology, Institute of Postgraduate Medical Education and Research, Kolkata, India., Sengupta M; Department of Pathology and Dermatology, Institute of Postgraduate Medical Education and Research, Kolkata, India., Addya S; Department of Pathology and Dermatology, Institute of Postgraduate Medical Education and Research, Kolkata, India., Chatterjee G; Department of Pathology and Dermatology, Institute of Postgraduate Medical Education and Research, Kolkata, India., Bandopadhyay M; Department of Pathology and Dermatology, Institute of Postgraduate Medical Education and Research, Kolkata, India. |
| Abstrakt: |
Vesiculobullous disorders could be either immunobullous or non-immunobullous. The spectrum was analyzed using histopathology, direct immunofluorescence (DIF), and salt-split technique. Among the 104 patients analyzed, 77 (74%) were immunobullous and 25 (24%) were having non-immunobullous diseases. Bullous pemphigoid (20.2%) is the commonest among immunobullous lesions, and epidermolysis bullosa (11.5%) was the most frequent non-immunobullous lesion. Involvement of the hair and nail and a positive family history were common relationships for non-immunobullous disorders. Immunobullous lesions showed DIF positivity whereas non-immunobullous lesions were DIF negative. Perilesional DIF was more sensitive and specific than lesional DIF. The commonest antibody was immunoglobulin G (IgG) (78.9%) followed by complement 3c (C3c) (38.1%), immunoglobulin A (IgA) (25%), and immunoglobulin M (IgM) (6.6%). No lesion should be considered non-immunobullous unless both lesional and perilesional DIF results were negative. |
