Combinatorial biosynthesis: playing chess with the metabolism.

Autor: Danaeifar M; Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 1416753955, Iran., Mazlomi MA; Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 1416753955, Iran.
Jazyk: angličtina
Zdroj: Journal of Asian natural products research [J Asian Nat Prod Res] 2023 Feb; Vol. 25 (2), pp. 171-190. Date of Electronic Publication: 2022 Apr 18.
DOI: 10.1080/10286020.2022.2065265
Abstrakt: Secondary metabolites are a group of natural products that produced by bacteria, fungi and plants. Many applications of these compounds from medicine to industry have been discovered. However, some changes in their structure and biosynthesis mechanism are necessary for their properties to be more suitable and also for their production to be profitable. The main and most useful method to achieve this goal is combinatorial biosynthesis. This technique uses the multi-unit essence of the secondary metabolites biosynthetic enzymes to make changes in their order, structure and also the organism that produces them.
Databáze: MEDLINE
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