[Lymphoepithelioma-like bladder tumor. A rare variant.]

Autor:	Salas E; Servicio de Urología. Hospital Universitario Miguel Servet. España., Enguita L; Servicio de Urología. Hospital Universitario Miguel Servet. España., Espílez R; Servicio de Urología. Hospital Universitario Miguel Servet. IIS-Aragón. España., Santander C; Servicio de Oncología Médica. Hospital Universitario Miguel Servet. España., Borque-Fernando Á; Servicio de Urología. Hospital Universitario Miguel Servet. IIS-Aragón. España., Gil MJ; Servicio de Urología. Hospital Universitario Miguel Servet. IIS-Aragón. España.
Jazyk:	Spanish; Castilian
Zdroj:	Archivos espanoles de urologia [Arch Esp Urol] 2022 Apr; Vol. 75 (3), pp. 300-305.
Abstrakt:	Introduction: Lymphoepitheliomalikedifferentiation is a rare histological variant of urothelialbladder carcinoma, therefore its prognosis and treatmentare not clearly defined. A retrospective study of 5cases in the last 10 years in our center was performed. Case Report: cystectomy was performed in 4 of5 because they were non-metastatic muscle-invasivetumors at diagnosis, in the 5th TURB + BCG because itwas non-muscle-invasive. 2 patients received chemotherapyand 1 adjuvant radiotherapy, and 1 immunotherapyafter relapse. 2 had a pure lymphoepithelioma-like pattern, 2 predominant and 1 focal. Discussion: In predominant or pure forms, agood response to treatment with TURB and adjuvantchemotherapy has been described, even superior tocystectomy, as it is a variant with a very favorable responseto platinum. Immunotherapy is currently onlyindicated as second-line treatment. Conclusions: adjuvant treatment plays an importantrole as it is a highly chemosensitive variant, but more studies are needed to define the best therapeuticstrategy.
Databáze:	MEDLINE
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