Plasma concentrations of tris(1-chloro-2-propyl) phosphate and a metabolite b is(2-chloroisopropyl) 1-carboxyethyl phosphate in Sprague-Dawley rats and B6C3F1/N mice from a chronic study of tris(chloropropyl) phosphate via feed.

Autor:	Collins B; National Institute of Environmental Health Sciences, Division of the National Toxicology Program, RTP, NC 27709-2233, USA., Slade D; MRIGlobal, Kansas City, MO 64110-2299, USA., Aillon K; MRIGlobal, Kansas City, MO 64110-2299, USA., Stout M; National Institute of Environmental Health Sciences, Division of the National Toxicology Program, RTP, NC 27709-2233, USA., Betz L; Social and Scientific Systems, Inc., Durham, NC 27703, USA., Waidyanatha S; National Institute of Environmental Health Sciences, Division of the National Toxicology Program, RTP, NC 27709-2233, USA., Ryan K; National Institute of Environmental Health Sciences, Division of the National Toxicology Program, RTP, NC 27709-2233, USA.
Jazyk:	angličtina
Zdroj:	Toxicology reports [Toxicol Rep] 2022 Mar 29; Vol. 9, pp. 690-698. Date of Electronic Publication: 2022 Mar 29 (Print Publication: 2022).
DOI:	10.1016/j.toxrep.2022.03.025
Abstrakt:	Tris(chloropropyl) phosphate (TCPP) is an organophosphorus flame retardant and plasticizer used in manufacturing and multiple consumer products. Commercial TCPP is a ubiquitous environmental contaminant and TCPP or its metabolites have been detected in human plasma and urine. In response to the demonstrated widespread human exposure and lack of toxicity data, the Division of the National Toxicology Program is investigating the chronic toxicity of TCPP following perinatal exposure in HSD:Sprague Dawley®SD® (HSD) rats (up to 20,000 ppm) and adult exposure in B6C3F1/N mice (females, up to 10,000 ppm; males up to 5000 ppm) to TCPP via feed. Systemic exposure and bioaccumulation were assessed by measuring plasma concentrations of tris(1-chloro-2-propyl)phosphate (TCIPP), the most abundant TCPP isomer. TCIPP concentrations in TCPP-exposed rats and mice ranged from 3.43 to 1180 ng/mL and increased with exposure concentration at all time points. No sex differences were observed in rats, but male mice had higher TCIPP concentrations than females. TCIPP did not bioaccumulate in rats or mice over the course of the study. Low TCIPP concentrations were seen in some control rats and mice that were attributed to background TCPP present during sample collection, preparation and/or analysis. Bis(2-chloroisopropyl) 1-carboxyethyl phosphate (BCPCP), a TCPP metabolite, was quantified in plasma from control and selected exposed animals. Results showed increases in BCPCP concentration that were proportional to exposure concentration in rats and mice at concentrations much higher than TCIPP, indicating that BCPCP might be a more suitable biomarker of TCPP exposure. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Databáze:	MEDLINE
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