Rapid 'on-column' preparation of hydrogen [ 11 C]cyanide from [ 11 C]methyl iodide via [ 11 C]formaldehyde.

Autor: Kikuchi T; Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology 4-9-1 Anagawa, Inage-ku Chiba 263-8555 Japan kikuchi.tatsuya@qst.go.jp., Ogawa M; Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology 4-9-1 Anagawa, Inage-ku Chiba 263-8555 Japan kikuchi.tatsuya@qst.go.jp.; SHI Accelerator Service, Ltd. 1-17-6 Osaki, Shinagawa-ku Tokyo 141-0032 Japan., Okamura T; Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology 4-9-1 Anagawa, Inage-ku Chiba 263-8555 Japan kikuchi.tatsuya@qst.go.jp., Gee AD; School of Biomedical Engineering and Imaging Sciences, King's College London 4th Floor Lambeth Wing, St Thomas' Hospital, Lambeth Palace Road London SE1 7EH UK., Zhang MR; Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology 4-9-1 Anagawa, Inage-ku Chiba 263-8555 Japan kikuchi.tatsuya@qst.go.jp.
Jazyk: angličtina
Zdroj: Chemical science [Chem Sci] 2022 Mar 08; Vol. 13 (12), pp. 3556-3562. Date of Electronic Publication: 2022 Mar 08 (Print Publication: 2022).
DOI: 10.1039/d1sc07033a
Abstrakt: Hydrogen [ 11 C]cyanide ([ 11 C]HCN) is a versatile 11 C-labelling agent for the production of 11 C-labelled compounds used for positron emission tomography (PET). However, the traditional method for [ 11 C]HCN production requires a dedicated infrastructure, limiting accessibility to [ 11 C]HCN. Herein, we report a simple and efficient [ 11 C]HCN production method that can be easily implemented in 11 C production facilities. The immediate production of [ 11 C]HCN was achieved by passing gaseous [ 11 C]methyl iodide ([ 11 C]CH 3 I) through a small two-layered reaction column. The first layer contained an N -oxide and a sulfoxide for conversion of [ 11 C]CH 3 I to [ 11 C]formaldehyde ([ 11 C]CH 2 O). The [ 11 C]CH 2 O produced was subsequently converted to [ 11 C]HCN in a second layer containing hydroxylamine- O -sulfonic acid. The yield of [ 11 C]HCN produced by the current method was comparable to that of [ 11 C]HCN produced by the traditional method. The use of oxymatrine and diphenyl sulfoxide for [ 11 C]CH 2 O production prevented deterioration of the molar activity of [ 11 C]HCN. Using this method, compounds labelled with [ 11 C]HCN are now made easily accessible for PET synthesis applications using readily available labware, without the need for the 'traditional' dedicated cyanide synthesis infrastructure.
Competing Interests: There are no conflicts to declare.
(This journal is © The Royal Society of Chemistry.)
Databáze: MEDLINE
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