Investigation of the Thermogelation of a Promising Biocompatible ABC Triblock Terpolymer and Its Comparison with Pluronic F127.

Autor: Constantinou AP; Department of Materials, Imperial College London, London SW7 2AZ, UK., Nele V; Department of Materials, Imperial College London, London SW7 2AZ, UK.; Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.; Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK., Doutch JJ; ISIS Neutron and Muon Source, STFC, Rutherford Appleton Laboratory, Didcot OX11 ODE, UK., S Correia J; Department of Materials, Imperial College London, London SW7 2AZ, UK., Moiseev RV; Reading School of Pharmacy, University of Reading, Whiteknights, P.O. Box 224, Reading RG66AD, UK., Cihova M; Department of Materials, Imperial College London, London SW7 2AZ, UK.; Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.; Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK., Gaboriau DCA; Facility for Imaging by Light Microscopy, NHLI, Imperial College London, London SW7 2AZ, UK., Krell J; Department of Surgery & Cancer, Imperial College London, London SW7 2AZ, UK., Khutoryanskiy VV; Reading School of Pharmacy, University of Reading, Whiteknights, P.O. Box 224, Reading RG66AD, UK., Stevens MM; Department of Materials, Imperial College London, London SW7 2AZ, UK.; Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.; Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK., Georgiou TK; Department of Materials, Imperial College London, London SW7 2AZ, UK.
Jazyk: angličtina
Zdroj: Macromolecules [Macromolecules] 2022 Mar 08; Vol. 55 (5), pp. 1783-1799. Date of Electronic Publication: 2022 Feb 14.
DOI: 10.1021/acs.macromol.1c02123
Abstrakt: Thermoresponsive polymers with the appropriate structure form physical networks upon changes in temperature, and they find utility in formulation science, tissue engineering, and drug delivery. Here, we report a cost-effective biocompatible alternative, namely OEGMA300 15 - b -BuMA 26 - b -DEGMA 13 , which forms gels at low concentrations (as low as 2% w/w); OEGMA300, BuMA, and DEGMA stand for oligo(ethylene glycol) methyl ether methacrylate (MM = 300 g mol -1 ), n -butyl methacrylate, and di(ethylene glycol) methyl ether methacrylate, respectively. This polymer is investigated in depth and is compared to its commercially available counterpart, Poloxamer P407 (Pluronic F127). To elucidate the differences in their macroscale gelling behavior, we investigate their nanoscale self-assembly by means of small-angle neutron scattering and simultaneously recording their rheological properties. Two different gelation mechanisms are revealed. The triblock copolymer inherently forms elongated micelles, whose length increases by temperature to form worm-like micelles, thus promoting gelation. In contrast, Pluronic F127's micellization is temperature-driven, and its gelation is attributed to the close packing of the micelles. The gel structure is analyzed through cryogenic scanning and transmission electron microscopy. Ex vivo gelation study upon intracameral injections demonstrates excellent potential for its application to improve drug residence in the eye.
Competing Interests: The authors declare the following competing financial interest(s): We (APC and TKG) have published a patent on this work that covers the novel combination of comonomers, i.e., the chemistry of the polymers.
(© 2022 American Chemical Society.)
Databáze: MEDLINE
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