Effects of Atezolizumab and Bevacizumab on Adrenal Gland Metastasis of Hepatocellular Carcinoma: A Case Report and Review of Literature.

Autor:	Ishikawa N; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan., Kamimura K; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan.; Department of General Medicine, Niigata University School of Medicine, Japan., Endo S; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan., Ishii S; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan., Ogawa K; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan., Sakai N; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan., Abe H; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan., Ko M; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan., Shibata O; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan., Koseki Y; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan., Yokoyama J; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan., Sakamaki A; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan., Terai S; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan.
Jazyk:	angličtina
Zdroj:	Internal medicine (Tokyo, Japan) [Intern Med] 2022 Nov 01; Vol. 61 (21), pp. 3233-3237. Date of Electronic Publication: 2022 Apr 16.
DOI:	10.2169/internalmedicine.9341-22
Abstrakt:	Regarding the prognosis of cases with advanced-stage hepatocellular carcinoma (HCC), a recent clinical study showed that the immune checkpoint inhibitors atezolizumab plus bevacizumab have superior efficacy to sorafenib. However, only a few reports have focused on their effects on extrahepatic metastases. We herein report a case of HCC in a 59-year-old man with intrahepatic lesions treated successfully by hepatic arterial chemoembolization, radiotherapy, and sorafenib; the extrahepatic lesion in the adrenal gland was treated by atezolizumab plus bevacizumab. The patient showed a tumor-free condition for one year. We have summarized the clinical course and reviewed the literature to underscore the efficacy of atezolizumab plus bevacizumab for treating extrahepatic lesions of HCC.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu