Clinical characteristics associated with the severity of Clostridium [Clostridioides] difficile infection in a tertiary teaching hospital from Mexico.

Autor:	Tijerina-Rodríguez L; Laboratorio de Microbiología General, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Mexico., Garza-González E; Servicio de Gastroenterología, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Mexico. Electronic address: elvira_garza_gzz@yahoo.com., Martínez-Meléndez A; Laboratorio de Microbiología General, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Mexico., Morfín-Otero R; Hospital Civil de Guadalajara, Fray Antonio Alcalde, Instituto de Patología Infecciosa y Experimental, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, Mexico., Camacho-Ortiz A; Servicio de Infectología, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Mexico., Gonzalez-Diaz E; Hospital Civil de Guadalajara, Fray Antonio Alcalde, Instituto de Patología Infecciosa y Experimental, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, Mexico., Perez-Gomez HR; Hospital Civil de Guadalajara, Fray Antonio Alcalde, Instituto de Patología Infecciosa y Experimental, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, Mexico., Villarreal-Treviño L; Laboratorio de Microbiología General, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Mexico., Maldonado-Garza H; Servicio de Gastroenterología, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Mexico., Esparza-Ahumada S; Hospital Civil de Guadalajara, Fray Antonio Alcalde, Instituto de Patología Infecciosa y Experimental, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, Mexico., Rodríguez-Noriega E; Hospital Civil de Guadalajara, Fray Antonio Alcalde, Instituto de Patología Infecciosa y Experimental, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, Mexico.
Jazyk:	angličtina
Zdroj:	Biomedical journal [Biomed J] 2022 Feb; Vol. 45 (1), pp. 200-205. Date of Electronic Publication: 2021 Feb 23.
DOI:	10.1016/j.bj.2021.02.007
Abstrakt:	Background: Clostridium difficile infection (CDI) is a leading cause of healthcare-associated diarrhea worldwide. In this study, risk factors associated with the development of severe-complicated and recurrent outcomes in CDI patients in different age groups, including the non-elderly, were assessed in a third-level hospital. Methods: CDI cases were detected by clinical data and polymerase-chain-reaction (PCR). Clinical, demographic, epidemiological, and microbiological risk factors for CDI were evaluated. Results: During the study period, 248 out of 805 patients with nosocomial diarrhea were diagnosed with CDI and the majority were severe-complicated cases (87.90%). Female gender (OR 3.19, 95% CI 1.19-8.55, p = 0.02) and lymphoma (OR 3.95, 95% CI 1.03-15.13, p = 0.04) were risk factors for severe-complicated CDI. Mature adulthood (51-60 years) (OR 5.80, 95% CI 1.56-21.62, p = 0.01), previous rifampicin use (OR 7.44, 95% CI 2.10-26.44, p = 0.00), and neoplasm (solid malignant neoplasm or hematological malignancies) (OR 4.12, 95% CI 1.01-16.83, p = 0.04) were risk factors for recurrent infection. Autoimmune disorders (OR 6.62, CI 95% 1.26-34.73, p = 0.02), leukemia (OR 4.97, 95% CI 1.05-23.58, p = 0.04), lymphoma (OR 3.79, 95% CI 1.03-12.07, p = 0.04) and previous colistin treatment (OR 4.97, 95% CI 1.05-23.58, p = 0.04) were risk factors for 30-day mortality. Conclusion: Newly identified risk factors for recurrent CDI were rifampicin treatment and age between 51 and 60 years; colistin treatment was identified as a risk factor for 30-day mortality. Previously identified risk factors for severe-complicated CDI were confirmed, but with a major impact on non-elderly patients. (Copyright © 2021 Chang Gung University. Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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