A preliminary biodistribution study of [ 99m Tc]sodium pertechnetate prepared from an electron linear accelerator and activated carbon-based 99m Tc generator.

Autor: Jang J; Department of Bioengineering, School of Engineering, University of Tokyo, Bunkyo, Tokyo 113-8656, Japan. Electronic address: jangj@korea.ac.kr., Kumakura Y; Department of Diagnostic Radiology and Nuclear Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350-8550, Japan; Isotope Science Center, University of Tokyo, Bunkyo, Tokyo 113-0032, Japan., Tatenuma K; Kaken Inc., Mito, Ibaraki 310-0903, Japan., Ozeki AN; Isotope Science Center, University of Tokyo, Bunkyo, Tokyo 113-0032, Japan., Wada Y; Isotope Science Center, University of Tokyo, Bunkyo, Tokyo 113-0032, Japan., Akimitsu N; Isotope Science Center, University of Tokyo, Bunkyo, Tokyo 113-0032, Japan., Tsuguchi A; Kaken Inc., Mito, Ibaraki 310-0903, Japan., Kikunaga H; Research Center for Electron Photon Science, Tohoku University, Sendai, Miyagi 982-0826, Japan., Higaki S; Isotope Science Center, University of Tokyo, Bunkyo, Tokyo 113-0032, Japan., Uesaka M; Department of Bioengineering, School of Engineering, University of Tokyo, Bunkyo, Tokyo 113-8656, Japan; Nuclear Professional School, School of Engineering, University of Tokyo, Naka, Ibaraki 319-1188, Japan.
Jazyk: angličtina
Zdroj: Nuclear medicine and biology [Nucl Med Biol] 2022 Jul-Aug; Vol. 110-111, pp. 1-9. Date of Electronic Publication: 2022 Mar 17.
DOI: 10.1016/j.nucmedbio.2022.03.002
Abstrakt: Introduction: Production of 99 Mo/ 99m Tc using an electron linear accelerator (linac) and activated carbon (AC)-based 99m Tc generator (linac-AC) is an alternative approach to the conventional fission production of 99 Mo/ 99m Tc. As a preliminary investigation of the clinical applicability of a linac-AC-derived 99m Tc radiopharmaceutical, the biodistribution of linac-AC-derived [ 99m Tc]sodium pertechnetate ([ 99m Tc]NaTcO 4 ) was measured and compared against fission-derived [ 99m Tc]NaTcO 4 at one time point.
Methods: 99 Mo was produced by irradiating nonenriched MoO 3 targets with bremsstrahlung photons generated from 55.5-MeV linac electron beams. 99m Tc was then separated and purified from the 99 Mo using an AC-based 99m Tc generator. Subsequently, biodistribution of the linac-AC-derived [ 99m Tc]NaTcO 4 in healthy female Slc:ICR mice (n = 6) was measured by dissection and compared with that of fission-derived [ 99m Tc]NaTcO 4 (n = 4) at 30 min after injection.
Results: The two types of [ 99m Tc]NaTcO 4 exhibited similar biodistribution in all the organs and tissues examined: the uptakes of [ 99m Tc]NaTcO 4 prepared from the linac-AC method and those prepared from the fission method were 138.9 ± 69.9%ID/g and 160.6 ± 49.2%ID/g in the thyroids, respectively, 33.4 ± 5.5%ID/g and 29.4 ± 9.1%ID/g in the salivary glands, respectively, and less than 10%ID/g in blood and all the other organs. No adverse effects were observed in the mice administered with either [ 99m Tc]NaTcO 4 .
Conclusion: The clinical applicability of linac-AC-derived [ 99m Tc]NaTcO 4 was suggested by its similar biodistribution with fission-derived [ 99m Tc]NaTcO 4 at one time point. Further biodistribution studies at multiple time points are encouraged to demonstrate the bioequivalence between linac-AC- and fission-derived [ 99m Tc]NaTcO 4 .
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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