25-Hydroxyvitamin D and metabolic-related laboratory values in women with schizophrenia and hyperprolactinemia.

Autor: Nallani MC; Department of Psychiatry, University of Maryland School of Medicine, USA., Powell MM; Department of Psychiatry, University of Maryland School of Medicine, USA., Pugh S; Department of Psychiatry, University of Maryland School of Medicine, USA., Kearns AM; Department of Psychiatry, University of Maryland School of Medicine, USA., Adams HA; Spring Grove Hospital Center and MPRC, Department of Psychiatry, University of Maryland School of Medicine, USA., Weiner E; Department of Psychiatry, University of Maryland School of Medicine, USA., Wehring HJ; Department of Psychiatry, University of Maryland School of Medicine, USA., McEvoy JP; Department of Psychiatry, Georgia Regents University, USA., Buckley PF; Department of Psychiatry, Virginia Commonwealth University School of Medicine, USA., Liu F; Department of Psychiatry, University of Maryland School of Medicine, USA., Buchanan RW; Department of Psychiatry, University of Maryland School of Medicine, USA., Kelly DL; Department of Psychiatry, University of Maryland School of Medicine, USA. Electronic address: dkelly@som.umaryland.edu.
Jazyk: angličtina
Zdroj: Journal of psychiatric research [J Psychiatr Res] 2022 Jul; Vol. 151, pp. 25-29. Date of Electronic Publication: 2022 Apr 08.
DOI: 10.1016/j.jpsychires.2022.03.046
Abstrakt: Schizophrenia is a severe mental disorder with various medical comorbidities and early mortality. Hyperprolactinemia is common in women and its impact on sexual function, galactorrhea and amenorrhea is well known. This paper evaluates the risk of 25-hydroxy vitamin D deficiency and other metabolic related laboratory abnormalities in women with schizophrenia having hyperprolactinemia (N = 43). The mean prolactin level in these women was 88.5 ± 56.0 ng/mL. We found that 100% of women were overweight of which 74% (32/43) of the women were obese, 56% (23/41) had abnormal total cholesterol levels and 30% (13/43) had high fasting blood glucose. Vitamin D levels were considered deficient or inadequate in 37% of women. We did not see significant correlations of prolactin with laboratory measures, however all female patients had elevated and high prolactin levels, leading to low variability in a small sample, which may have precluded seeing any direct relationships. Recognizing prolactin related side effects and understanding the role of other health measures seen in women with antipsychotic induced hyperprolactinemia in our female patients are critical steps toward better personalization of their care and recovery.
(Copyright © 2022. Published by Elsevier Ltd.)
Databáze: MEDLINE
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