Biologics in the Treatment of Uveitis.
| Autor: | Dingerkus VLS; Department für Augenheilkunde, Stadtspital Zürich, Zürich, Schweiz., Becker MD; Department für Augenheilkunde, Stadtspital Zürich, Zürich, Schweiz.; Department für Augenheilkunde, Universitätsklinikum Heidelberg, Deutschland., Doycheva D; Department für Augenheilkunde, Universitätsklinikum Tübingen, Deutschland. |
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| Jazyk: | English; German |
| Zdroj: | Klinische Monatsblatter fur Augenheilkunde [Klin Monbl Augenheilkd] 2022 May; Vol. 239 (5), pp. 686-694. Date of Electronic Publication: 2022 Apr 14. |
| DOI: | 10.1055/a-1737-4425 |
| Abstrakt: | Goal: To provide an overview of biologics that are used to treat noninfectious uveitis, including their different targets, modes of actions, and indications. Material and Methods: A review of recent and well-established literature was used to present the biochemical and pathophysiological background of biologics and to provide an account of evidence-based decision making for their use, not only in noninfectious uveitis in general, but with special regard to indications for their use in particular types of uveitis. Results: Extensive clinical data for adalimumab shows that it is currently the only approved biologic for the treatment of uveitis. However, there is sufficient evidence to argue that many other biologics, notably TNF-α inhibitors, certain Interleukin inhibitors, Interferons, and B cell and T cell inhibitors, are also suitable for use in uveitis. Conclusions: Biologics have revolutionized the treatment of noninfectious uveitis and are now considered indispensable. They are used in cases of insufficient response to or intolerance of conventional immunosuppressive agents. However, they can also be indicated as a first-line therapy for certain types of uveitis (e.g., Behçet's disease). TNF-α inhibitors are the most commonly used biologics in the treatment of uveitis. Competing Interests: Prof. Matthias Dieter Becker: Firma Roche. (Thieme. All rights reserved.) |
| Databáze: | MEDLINE |
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