Epidemiology and outcomes of pneumococcal sepsis in children with nephrotic syndrome in a developing country.

Autor: Mathew G; Department of Pediatric Nephrology, Christian Medical College, Vellore, India. georgie.mathew@cmcvellore.ac.in., George AS; Department of Pediatric Nephrology, Christian Medical College, Vellore, India., Deepthi RV; Department of Pediatric Nephrology, Christian Medical College, Vellore, India., Rose W; Department of Pediatric Infectious Diseases, Christian Medical College, Vellore, India., Verghese VP; Department of Pediatric Infectious Diseases, Christian Medical College, Vellore, India., Varghese R; Department of Clinical Microbiology, Christian Medical College, Vellore, India., Veeraraghavan B; Department of Clinical Microbiology, Christian Medical College, Vellore, India., Agarwal I; Department of Pediatric Nephrology, Christian Medical College, Vellore, India.
Jazyk: angličtina
Zdroj: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2023 Jan; Vol. 38 (1), pp. 131-137. Date of Electronic Publication: 2022 Apr 14.
DOI: 10.1007/s00467-022-05550-0
Abstrakt: Background: Pneumococcal infections are common in children with nephrotic syndrome. Knowledge of the commonly available serotypes and antibiotic susceptibility will help in prevention and appropriate management of pneumococcal sepsis, especially in resource-limited countries.
Methods: Demographic, clinical, and laboratory data on children with nephrotic syndrome and pneumococcal infections were extracted from the electronic medical records.
Results: Sixty-three isolates of pneumococci obtained from 60 children with nephrotic syndrome, over a period of 14 years, were included in the study. This represented 18% of all pneumococcal infections occurring in children during the same period. Commonly available vaccines covered up to 58% of all the serotypes causing infection. Severe disease, with shock, intensive care admission and/or meningitis, was observed in 38% children and mortality was observed in 10%. Resistance to commonly used antibiotics was not observed, except for erythromycin.
Conclusions: Pneumococcal sepsis was observed to be common in children with nephrotic syndrome and results in significant morbidity and mortality. Commonly used antibiotics were observed to be effective in management of the infections.
(© 2022. The Author(s), under exclusive licence to International Pediatric Nephrology Association.)
Databáze: MEDLINE
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