Drinking water chlorination has minor effects on the intestinal flora and resistomes of Bangladeshi children.

Autor: Nadimpalli ML; Department of Civil and Environmental Engineering, Tufts University, Medford, MA, USA.; Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance (Levy CIMAR), Tufts University, Boston, MA, USA., Lanza VF; Bioinformatics Unit, Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain.; Network Research Center for Infectious Diseases (CIBERINFEC), Madrid, Spain., Montealegre MC; Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland., Sultana S; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Fuhrmeister ER; Department of Civil and Environmental Engineering, Tufts University, Medford, MA, USA., Worby CJ; Infectious Disease & Microbiome Program, Broad Institute, Cambridge, MA, USA., Teichmann L; Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland., Caduff L; Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland., Swarthout JM; Department of Civil and Environmental Engineering, Tufts University, Medford, MA, USA., Crider YS; Energy and Resources Group, University of California Berkeley, Berkeley, CA, USA.; King Center on Global Development, Stanford University, Stanford, CA, USA., Earl AM; Infectious Disease & Microbiome Program, Broad Institute, Cambridge, MA, USA., Brown J; Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Luby SP; Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA., Islam MA; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.; Paul G. Allen School for Global Health, Washington State University, Pullman, WA, USA., Julian TR; Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland. tim.Julian@eawag.ch.; Swiss Tropical and Public Health Institute, Basel, Switzerland. tim.Julian@eawag.ch.; University of Basel, Basel, Switzerland. tim.Julian@eawag.ch., Pickering AJ; Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance (Levy CIMAR), Tufts University, Boston, MA, USA. pickering@berkeley.edu.; Department of Civil and Environmental Engineering, University of California, Berkeley, CA, USA. pickering@berkeley.edu.; Blum Center for Developing Economies, University of California, Berkeley, CA, USA. pickering@berkeley.edu.
Jazyk: angličtina
Zdroj: Nature microbiology [Nat Microbiol] 2022 May; Vol. 7 (5), pp. 620-629. Date of Electronic Publication: 2022 Apr 14.
DOI: 10.1038/s41564-022-01101-3
Abstrakt: Healthy development of the gut microbiome provides long-term health benefits. Children raised in countries with high infectious disease burdens are frequently exposed to diarrhoeal pathogens and antibiotics, which perturb gut microbiome assembly. A recent cluster-randomized trial leveraging >4,000 child observations in Dhaka, Bangladesh, found that automated water chlorination of shared taps effectively reduced child diarrhoea and antibiotic use. In this substudy, we leveraged stool samples collected from 130 children 1 year after chlorine doser installation to examine differences between treatment and control children's gut microbiota. Water chlorination was associated with increased abundance of several bacterial genera previously linked to improved gut health; however, we observed no effects on the overall richness or diversity of taxa. Several clinically relevant antibiotic resistance genes were relatively more abundant in the gut microbiome of treatment children, possibly due to increases in Enterobacteriaceae. While further studies on the long-term health impacts of drinking chlorinated water would be valuable, we conclude that access to chlorinated water did not substantially impact child gut microbiome development in this setting, supporting the use of chlorination to increase global access to safe drinking water.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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