Sufentanil for carboprost-induced adverse reactions during cesarean delivery under combined spinal-epidural anesthesia.

Autor:	Hu Q; Laboratory of Molecular Translational Medicine, Centre for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Clinical Research Center for Birth Defects of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China, China., Guo J; The second Affiliated hospital of Zhejiang University School of medicine, Hangzhou, Zhejiang, P.R. China., Bai P; Department of Forensic Genetics, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, P.R. China., Xiao X; Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, P.R. China.; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu, P.R. China., He T; Department of Anesthesiology, West China Second University Hospital, Sichuan University, Chengdu, P.R. China., Yang P; Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, P.R. China., Li H; Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, P.R. China.; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu, P.R. China., Zhang L; Laboratory of Molecular Translational Medicine, Centre for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Clinical Research Center for Birth Defects of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China, China.
Jazyk:	angličtina
Zdroj:	Ginekologia polska [Ginekol Pol] 2023; Vol. 94 (5), pp. 379-388. Date of Electronic Publication: 2022 Apr 14.
DOI:	10.5603/GP.a2021.0262
Abstrakt:	Objectives: Carboprost plays an important role in managing refractory uterine atony and severe postpartum hemorrhage. However, it is associated with challenging adverse reactions. We aimed to evaluate the clinical effects of low dose sufentanil on the prevention of adverse events associated with carboprost during cesarean delivery. Material and Methods: Patients were randomly divided into two groups: a placebo control group (group C, n = 15) that received an intravenous infusion of 1 mL of normal saline 2 min before carboprost and a sufentanil group (group S, n = 15) that received 5 μg of sufentanil. The primary outcome was the incidence of nausea and vomiting following carboprost administration. Results: The incidence of nausea, vomiting, and gastrointestinal discomfort was significantly lower in group S than in group C (p < 0.05). Conclusions: The prophylactic use of low dose sufentanil reduces the incidence of gastrointestinal side effects caused by carboprost administration during cesarean section.
Databáze:	MEDLINE
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