Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.

Autor: Simeoni F; Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK., Somervaille TC; Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
Jazyk: angličtina
Zdroj: Molecular & cellular oncology [Mol Cell Oncol] 2021 Nov 19; Vol. 8 (6), pp. 2003161. Date of Electronic Publication: 2021 Nov 19 (Print Publication: 2021).
DOI: 10.1080/23723556.2021.2003161
Abstrakt: Tissue-inappropriate expression of FOXC1 (Forkhead Box C1) in acute myeloid leukemia confers a monocyte/macrophage lineage differentiation block. We discovered that FOXC1 interacts with RUNX1 (Runt-Related Transcription Factor 1) to stabilize a RUNX1, HDAC1 (Histone Deacetylase 1) and TLE3 (Transducin-like enhancer protein 3) repressor complex at enhancers controlling myeloid differentiation genes.
Competing Interests: No potential conflict of interest was reported by the author(s).
(© 2021 Taylor & Francis Group, LLC.)
Databáze: MEDLINE
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