| Autor: |
Zazadze R; 1Tbilisi State Medical University, Department of Pharmaceutical Technologies; Georgia., Bakuridze L; 1Tbilisi State Medical University, Department of Pharmaceutical Technologies; Georgia., Chavelashvili L; 1Tbilisi State Medical University, Department of Pharmaceutical Technologies; Georgia., Gongadze N; 2Tbilisi State Medical University, Department of Medical Pharmacology, Georgia., Bakuridze A; 1Tbilisi State Medical University, Department of Pharmaceutical Technologies; Georgia. |
| Jazyk: |
angličtina |
| Zdroj: |
Georgian medical news [Georgian Med News] 2022 Mar (324), pp. 192-197. |
| Abstrakt: |
An acid fraction derived from the evergreen plant of Mastic gum(Pistacia lentiscus L., family Anacardiacae, genus Pistacis L.) has been found to have bactericidal activity against 11 strains of Helicobacter pylori. However its healing potential is significantly reduced by poor solubility and low biological penetration. Therefore, the current problem is to develop a system that provides increased penetration of the drug into the stomach through the epithelial barrier. Foams are especially interesting in this regard. Foams are light systems, they do not swell, on the contrary, they grow in volume, completely covering the mucous membrane. The foams do not require taste correction and are designed to deliver a therapeutic substance from the skin and mucous membranes and provide an effective treatment. The aim of the research was the determination of formulation and development of technology of innovative medicinal form from Mastic gum. Based on biopharmaceutical studies, the formulation of capsules containing a foaming powder composition was determined: Mastic gum 250.0; Sodium lauryl sulfate (SLS) - 9.0; Lecithin - 12.6; Xanthan 4.5; Gelatin 4.5; Isomalt 90.0; Dry egg whites - 41.0; Sodium bicarbonate - 21.0; Citric acid - 6.0; Metocell M102 - 10.0; Talc - 1,4. The technology of preparation of Mastic gum foaming powder containing capsules has been developed.Foaming capsules containing Mastic gum, in artificial gastric juice, with foam-forming ability and foam stability meet the standard requirements for foam systems. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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