Chaotic and stochastic dynamics of epileptiform-like activities in sclerotic hippocampus resected from patients with pharmacoresistant epilepsy.

Autor: Araújo NS; Department of Neurology and Neurosurgery, Federal University of São Paulo (UNIFESP), São Paulo, São Paulo, Brazil., Reyes-Garcia SZ; Departamento de Ciencias Morfológicas, Facultad de Ciencias Médicas, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras., Brogin JAF; Department of Mechanical Engineering, São Paulo State University (UNESP), School of Engineering of Ilha Solteira, Ilha Solteira, São Paulo, Brazil., Bueno DD; Department of Mathematics, São Paulo State University (UNESP), School of Engineering of Ilha Solteira, Ilha Solteira, São Paulo, Brazil., Cavalheiro EA; Department of Neurology and Neurosurgery, Federal University of São Paulo (UNIFESP), São Paulo, São Paulo, Brazil., Scorza CA; Department of Neurology and Neurosurgery, Federal University of São Paulo (UNIFESP), São Paulo, São Paulo, Brazil., Faber J; Department of Neurology and Neurosurgery, Federal University of São Paulo (UNIFESP), São Paulo, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: PLoS computational biology [PLoS Comput Biol] 2022 Apr 13; Vol. 18 (4), pp. e1010027. Date of Electronic Publication: 2022 Apr 13 (Print Publication: 2022).
DOI: 10.1371/journal.pcbi.1010027
Abstrakt: The types of epileptiform activity occurring in the sclerotic hippocampus with highest incidence are interictal-like events (II) and periodic ictal spiking (PIS). These activities are classified according to their event rates, but it is still unclear if these rate differences are consequences of underlying physiological mechanisms. Identifying new and more specific information related to these two activities may bring insights to a better understanding about the epileptogenic process and new diagnosis. We applied Poincaré map analysis and Recurrence Quantification Analysis (RQA) onto 35 in vitro electrophysiological signals recorded from slices of 12 hippocampal tissues surgically resected from patients with pharmacoresistant temporal lobe epilepsy. These analyzes showed that the II activity is related to chaotic dynamics, whereas the PIS activity is related to deterministic periodic dynamics. Additionally, it indicates that their different rates are consequence of different endogenous dynamics. Finally, by using two computational models we were able to simulate the transition between II and PIS activities. The RQA was applied to different periods of these simulations to compare the recurrences between artificial and real signals, showing that different ranges of regularity-chaoticity can be directly associated with the generation of PIS and II activities.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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