[Determination of zaleplon and clobazam by high performance liquid chromatography - high resolution tandem mass spectrometry using Orbitrap technology].

Autor:	Kalyokin RA; Russian Center of Forensic Medical Expertise, Moscow, Russia., Moskaleva NE; Russian Center of Forensic Medical Expertise, Moscow, Russia.; Sechenov First Moscow State Medical University, Moscow, Russia., Volkova AA; Russian Center of Forensic Medical Expertise, Moscow, Russia., Orlova AM; Russian Center of Forensic Medical Expertise, Moscow, Russia., Markin PA; Russian Center of Forensic Medical Expertise, Moscow, Russia.; Sechenov First Moscow State Medical University, Moscow, Russia., Nevmyatova SR; Sechenov First Moscow State Medical University, Moscow, Russia., Appolonova SA; Russian Center of Forensic Medical Expertise, Moscow, Russia.; Sechenov First Moscow State Medical University, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Sudebno-meditsinskaia ekspertiza [Sud Med Ekspert] 2022; Vol. 65 (2), pp. 24-28.
DOI:	10.17116/sudmed20226502124
Abstrakt:	The Aim of the Study: Was to develop a method for the qualitative and quantitative determination of benzodiazepine receptor agonists (zaleplon and clobazam), taking into account different chemical structures, by high-performance liquid chromatography-high-resolution tandem mass spectrometry using Orbitrap technology for the purposes and tasks of forensic medical examination. A method has been developed for the identification and quantitative determination of zaleplon and clobazam by high-performance liquid chromatography-high-resolution tandem mass spectrometry using Orbitrap technology. The proposed identification method can be used in the future to form a database of domestic mass spectra for potent and narcotic substances.
Databáze:	MEDLINE
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