Characterization of cerebrospinal fluid biomarkers associated with neurodegenerative diseases in healthy cynomolgus and rhesus macaque monkeys.

Autor: Robertson EL; Centre for Neuroscience Studies Queen's University Kingston Ontario Canada., Boehnke SE; Centre for Neuroscience Studies Queen's University Kingston Ontario Canada.; Department of Biomedical and Molecular Sciences Queen's University Kingston Ontario Canada., Lyra E Silva NM; Centre for Neuroscience Studies Queen's University Kingston Ontario Canada.; Department of Biomedical and Molecular Sciences Queen's University Kingston Ontario Canada., Armitage-Brown B; Centre for Neuroscience Studies Queen's University Kingston Ontario Canada.; Animal Care Services Queen's University Kingston Ontario Canada., Winterborn A; Animal Care Services Queen's University Kingston Ontario Canada., Cook DJ; Centre for Neuroscience Studies Queen's University Kingston Ontario Canada.; Department of Surgery Kingston Health Sciences Centre Kingston Ontario Canada., De Felice FG; Centre for Neuroscience Studies Queen's University Kingston Ontario Canada.; Department of Biomedical and Molecular Sciences Queen's University Kingston Ontario Canada.; Institute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro, Cidade Universitaria - Rio de Janeiro Rio de Janeiro Brazil.; D'OR Institute for Research and Education Rio de Janeiro Brazil.; Department of Psychiatry Providence Care Hospital Kingston Ontario Canada., Munoz DP; Centre for Neuroscience Studies Queen's University Kingston Ontario Canada.; Department of Biomedical and Molecular Sciences Queen's University Kingston Ontario Canada.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2022 Apr 05; Vol. 8 (1), pp. e12289. Date of Electronic Publication: 2022 Apr 05 (Print Publication: 2022).
DOI: 10.1002/trc2.12289
Abstrakt: Monkeys are becoming important translational models of neurodegenerative disease. To facilitate model development, we measured cerebrospinal fluid (CSF) concentrations of key biomarkers in healthy male and female cynomolgus and rhesus macaques. Amyloid beta (Aβ40, Aβ42), tau (total tau [t-tau], phosphorylated tau [pThr181]), and neurofilament light (NfL) concentrations were measured in CSF of 82 laboratory-housed, experimentally naïve cynomolgus (n = 33) and rhesus (n = 49) macaques. Aβ40 and Aβ42 were significantly higher in rhesus, and female rhesus were higher than males. NfL and t-tau were higher in males, and NfL was higher in rhesus macaques. p-tau was not affected by species or sex. We also examined whether sample location (lumbar or cisterna puncture) affected concentrations. Sample acquisition site only affected NfL, which was higher in CSF from lumbar puncture compared to cisterna magna puncture. Establishing normative biomarker values for laboratory-housed macaque monkeys provides an important resource by which to compare to monkey models of neurodegenerative diseases.
Competing Interests: Emma L. Robertson and Andrew Winterborn: none to disclose. Susan E. Boehnke received funding for unrelated research from the Social Sciences and Humanities Research Council (SSHRC, to Queen's University) and Wicked Ideas grant (Queen's University, to Queen's University). Natalia M. Lyra e Silva: received funding for unrelated research from Canadian Institutes of Health Research (CIHR). Brittney Armitage‐Brown received funding for unrelated research from Animal Welfare Institute refinement grant and support from Queen's University to attend a conference. Douglas J. Cook received funding for unrelated research from Natural Sciences and Engineering Research Council (NSERC, to Queen's University) and the National Research Council's Industrial Research Assistance Program (NRC IRAC, to Queen's University). Fernanda G. De Felice received funding for unrelated research from Canadian Institutes of Health Research (CIHR), Alzheimer's Society Canada, and the Weston Brain Institute (all to Queen's University) and the National Institute for Translational Neuroscience (INNT/Brazil), the Brazilian funding agencies Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) (all to Universidade Federal do Rio de Janeiro). Douglas P. Munoz received grant funding for this research from Canadian Institutes of Health Research (to Queen's University), Canada Research Chairs Program, and Brain Canada (to Queen's University), and from the Ontario Brain Institute (to Queen's University) for other projects; received an honorarium from Western University for reviewing grants; and has a patent on “Methods and Apparatus for Detecting Brain Disorders. A method for using video‐based eye tracking to help diagnose brain disorders.”
(© 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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