Global improvement in meibomian glands after chalazion surgery demonstrated by meibography.

Autor: Hanna S; Ophthalmology Department, Baruch Padeh Medical Center, Dov Hoz 0., 15208, Poriya, Israel., Hartstein M; Ophthalmology Department, Shamir Medical Center, Tzrifin, Israel., Mukari A; Estemed Clinic, Kfar Kanna, Israel., Shor S; Ophthalmology Department, Baruch Padeh Medical Center, Dov Hoz 0., 15208, Poriya, Israel., Habib G; Rheumatology Unit, Laniado hospital, Netanya, Israel., Hamed Azzam S; Ophthalmology Department, Baruch Padeh Medical Center, Dov Hoz 0., 15208, Poriya, Israel. shirinhamedazzam@gmail.com.
Jazyk: angličtina
Zdroj: International ophthalmology [Int Ophthalmol] 2022 Aug; Vol. 42 (8), pp. 2591-2598. Date of Electronic Publication: 2022 Apr 12.
DOI: 10.1007/s10792-022-02307-4
Abstrakt: Purpose: To evaluate the use of meibography as an objective measure of the effects of incision & curettage (I&C) chalazion surgery on meibomian gland loss and morphology as well as dry eye syndrome.
Methods: This prospective, interventional clinical study included adult patients with a primary chalazion which persisted despite conservative treatment. All patients underwent I&C surgery. The following parameters were compared both preoperatively and 21 days postoperatively: meibography, tear breakup time (TBUT), Schirmer test, meibum expression, tear meniscus height, meibomian gland dysfunction (MGD) grading, and the Ocular Surface Disease Index (OSDI).
Results: Thirty eyelids were enrolled in the study. The mean age ± SD was 40.56 ± 13.94 years. Meibography demonstrated a significant decrease in meibomian gland loss (P = 0.00) and improvement in morphology. The most common meibomian gland pathology preoperatively noted was morphological signs of atrophy that included fluffy areas and tortuous glands. Both of these findings improved postoperatively (P = 0.04 and P = 0.02, respectively). There were a significant change in MGD grading and a significant decrease in meibum expression score postoperatively (P = 0.00). TBUT and tear meniscus height also improved significantly (P = 0.00 and P = 0.003, respectively). The OSDI score improved significantly as well (P = 0.00).
Conclusion: While incision and drainage surgery is a time-honored, standard treatment for chalazion, meibography now demonstrates a global improvement in the meibomian glands, not just the ones involved with the chalazion. In addition to the improvements in the clinical and dry eye syndrome parameters improvements, meibography findings demonstrate that early I&C surgery restores the meibomian glands architecture significantly.
(© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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