Intraclass correlation coefficients for weight loss cluster randomized trials in primary care: The PROPEL trial.

Autor: Katzmarzyk PT; Pennington Biomedical Research Centre, Baton Rouge, LA, USA., Denstel KD; Pennington Biomedical Research Centre, Baton Rouge, LA, USA., Martin CK; Pennington Biomedical Research Centre, Baton Rouge, LA, USA., Newton RL Jr; Pennington Biomedical Research Centre, Baton Rouge, LA, USA., Apolzan JW; Pennington Biomedical Research Centre, Baton Rouge, LA, USA., Mire EF; Pennington Biomedical Research Centre, Baton Rouge, LA, USA., Horswell R; Pennington Biomedical Research Centre, Baton Rouge, LA, USA., Johnson WD; Pennington Biomedical Research Centre, Baton Rouge, LA, USA., Brown AW; Department of Applied Health Science, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA., Zhang D; Pennington Biomedical Research Centre, Baton Rouge, LA, USA.
Jazyk: angličtina
Zdroj: Clinical obesity [Clin Obes] 2022 Aug; Vol. 12 (4), pp. e12524. Date of Electronic Publication: 2022 Apr 12.
DOI: 10.1111/cob.12524
Abstrakt: The aim of this study was to compute intra-class correlations (ICCs) for weight-related and patient-reported outcomes in a cluster randomized clinical trial (cRCT) for weight loss. Baseline and follow-up data from the Promoting Successful Weight Loss in Primary Care in Louisiana (PROPEL) cRCT were used in this analysis. ICCs were computed for baseline and follow-up measures, and changes in body weight, cardiometabolic risk factors and health-related and weight-related quality of life at 6, 12, 18 and 24 months. Baseline ICCs ranged from 0 for PROMIS measures of anxiety and fatigue to 0.055 for total cholesterol (median = 0.019). The ICCs were higher for changes and decreased over time during follow-up. The ICCs for changes were highest in the pooled sample (intervention and usual care combined) followed by the intervention and usual care groups, respectively. The results demonstrated significant ICCs for several outcomes in a weight loss cRCT. The ICCs differed in magnitude depending on whether baseline versus longitudinal data were used, whether data were combined across treatment arms or were considered separately, and varied across the follow-up period. All these factors must be considered when choosing an ICC to inform sample size estimates for future weight loss cRCTs conducted in primary care settings.
(© 2022 World Obesity Federation.)
Databáze: MEDLINE
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