Lymphovascular and perineural invasion are risk factors for inguinal lymph node metastases in men with T1G2 penile cancer.

Autor: Fankhauser CD; Department of Urology, The Christie NHS Foundation Trust, Manchester, UK. cdfankhauser@gmail.com.; Department of Urology, Luzerner Kantonsspital, University of Lucerne, Lucerne, Switzerland. cdfankhauser@gmail.com.; University of Zurich, Zurich, Switzerland. cdfankhauser@gmail.com.; Luzerner Kantonsspital, Luzern, Switzerland. cdfankhauser@gmail.com., de Vries HM; Department of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands., Roussel E; Department of Urology, University Hospitals Leuven, Leuven, Belgium., Jakobsen JK; Department of Urology, Aarhus University Hospital, Aarhus, Denmark., Issa A; Department of Urology, The Christie NHS Foundation Trust, Manchester, UK., Lee EWC; Department of Urology, The Christie NHS Foundation Trust, Manchester, UK., Schifano N; NIHR Biomedical Research Centre, University College London Hospital, London, UK.; Department of Urology, University College London Hospital, London, UK.; Division of Surgery and Interventional Science, UCL, London, UK., Alnajjar H; NIHR Biomedical Research Centre, University College London Hospital, London, UK.; Department of Urology, University College London Hospital, London, UK.; Division of Surgery and Interventional Science, UCL, London, UK., Castiglione F; NIHR Biomedical Research Centre, University College London Hospital, London, UK.; Department of Urology, University College London Hospital, London, UK.; Division of Surgery and Interventional Science, UCL, London, UK., Antonelli L; Department of Urology, Luzerner Kantonsspital, University of Lucerne, Lucerne, Switzerland.; Department of Urology, Policlinico Umberto I, Rome, Italy., Oliveira P; Department of Pathology, The Christie NHS Foundation Trust, Manchester, UK., Lau M; Department of Urology, The Christie NHS Foundation Trust, Manchester, UK., Parnham A; Department of Urology, The Christie NHS Foundation Trust, Manchester, UK., Albersen M; Department of Urology, University Hospitals Leuven, Leuven, Belgium., Watkin NA; Department of Urology, St George's Hospital, London, UK., Muneer A; NIHR Biomedical Research Centre, University College London Hospital, London, UK.; Department of Urology, University College London Hospital, London, UK.; Division of Surgery and Interventional Science, UCL, London, UK., Ayres BE; Department of Urology, St George's Hospital, London, UK., Brouwer OR; Department of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands., Sangar V; Department of Urology, The Christie NHS Foundation Trust, Manchester, UK.; Manchester Academic Health Sciences Centre, Manchester, UK.
Jazyk: angličtina
Zdroj: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2022 Sep; Vol. 148 (9), pp. 2231-2234. Date of Electronic Publication: 2022 Apr 12.
DOI: 10.1007/s00432-022-04012-2
Abstrakt: Purpose: To analyse the risk of inguinal lymph node (ILN) metastases in T1G2 penile cancer stratified by lymphovascular invasion (LVI), perineural invasion (PNI) and tumour size.
Methods: Retrospective study of men with localised T1G2 penile cancer with non-palpable lymph nodes and no local recurrence during follow-up at six European institutional high-volume centres was performed. ILN involvement was defined as cancer detected during ultrasound-guided fine-needle aspiration cytology, core needle biopsy, dynamic sentinel lymph node biopsy, ILN dissection or inguinal recurrence during follow-up. Uni- and multivariable logistic regression analyses were performed.
Results: In the cohort of 554 men with T1G2 penile cancer, from 6 European institutions, ILN metastases were observed in 46/554 men (8%, 95% confidence interval (CI) 6-11%). Men with both, LVI- and PNI- primary cancers had the lowest risk of ILN involvement (6%) whereas men with LVI + or PNI + showed ILN metastases in 22% and 30%. In multivariable regression, men with LVI + or PNI + had higher odds for ILN metastases compared to men with LVI- and PNI- (OR 3.9, 95% CI 1.6-9.0, p value < 0.01) Tumour size was not associated with ILN risk (OR 1.01 95% CI 0.99-1.04, p = 0.17).
Conclusion: Approximately, one out of ten men with T1G2 overall and one out of four men with either LVI + or PNI + still have ILN metastases despite being clinically node negative. Therefore, invasive ILN staging should strongly be recommended in T1G2 with LVI + or PNI + but importantly, must be discussed in patients with T1G2 with LVI- or PNI-.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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