Lung Transplant in a Patient With Multifocal Langerhans Cell Histiocytosis After Chemotherapy With Cladribine: A Case Report.

Autor: Abba ME; Medical University of Gdańsk, Gdańsk, Poland. Electronic address: maiaene.abba@gmail.com., Żegleń S; Department of Histology, Institute of Medical Sciences, University of Opole, Opole, Poland; Department of Pneumonology and Allergology, Medical University of Gdańsk, Gdańsk, Poland., Łącka M; Medical University of Gdańsk, Gdańsk, Poland., Maruszewski M; Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszyński University in Warsaw, Warsaw, Poland; Department of Cardiac Surgery and Vascular Surgery, Medical University of Gdańsk, Gdańsk, Poland., Kowalski J; Department of Pathology, Medical University of Gdańsk, Gdańsk, Poland., Stachowicz-Chojnacka K; Department of Cardiac Surgery and Vascular Surgery, Medical University of Gdańsk, Gdańsk, Poland., Wojarski J; Department of Cardiac Surgery and Vascular Surgery, Medical University of Gdańsk, Gdańsk, Poland., Ulatowski N; Department of Cardiac Surgery and Vascular Surgery, Medical University of Gdańsk, Gdańsk, Poland., Karolak W; Department of Cardiac Surgery and Vascular Surgery, Medical University of Gdańsk, Gdańsk, Poland.
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2022 May; Vol. 54 (4), pp. 1177-1179. Date of Electronic Publication: 2022 Apr 08.
DOI: 10.1016/j.transproceed.2022.02.037
Abstrakt: Langerhans cell histiocytosis (LCH) is a rare inflammatory disorder of myeloid dendritic cells with mutations involving KRAS, BRAF and/or NRAS, and MAP2K1 genes. We describe the case of a 58-year-old female previous smoker with multifocal LCH involving the lungs, pituitary gland and mandibular bone. Initial treatment with 6 cycles of cladribine showed improvement in her extrapulmonary lesions, however, her lung disease progressed and after qualification and assessment tests she underwent uncomplicated double lung transplant surgery and was discharged home. We highlight that in select patients with well managed and controlled extrapulmonary LCH, such an invasive procedure as lung transplant is possible.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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