Aerobic exercise and telomere length in patients with systolic heart failure: protocol study for a randomized controlled trial.

Autor: Franzoni LT; Post-Graduate Program in Sciences: Cardiology and Cardiovascular Sciences, Porto Alegre, Brazil. lfranzoni@hcpa.edu.br.; Clinic Hospital of Porto Alegre, Porto Alegre, Brazil. lfranzoni@hcpa.edu.br.; Federal University of Rio Grande do Sul, Porto Alegre, Brazil. lfranzoni@hcpa.edu.br.; Porto Alegre, Brazil. lfranzoni@hcpa.edu.br., Garcia EL; Clinic Hospital of Porto Alegre, Porto Alegre, Brazil., Motta SB; Clinic Hospital of Porto Alegre, Porto Alegre, Brazil., Ahner MM; Clinic Hospital of Porto Alegre, Porto Alegre, Brazil., Bertoletti OA; Clinic Hospital of Porto Alegre, Porto Alegre, Brazil., Saffi MAL; Post-Graduate Program in Sciences: Cardiology and Cardiovascular Sciences, Porto Alegre, Brazil.; Federal University of Rio Grande do Sul, Porto Alegre, Brazil., da Silveira AD; Post-Graduate Program in Sciences: Cardiology and Cardiovascular Sciences, Porto Alegre, Brazil.; Clinic Hospital of Porto Alegre, Porto Alegre, Brazil.; Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Pereira AA; Post-Graduate Program in Sciences: Cardiology and Cardiovascular Sciences, Porto Alegre, Brazil.; Clinic Hospital of Porto Alegre, Porto Alegre, Brazil., Pereira AH; Clinic Hospital of Porto Alegre, Porto Alegre, Brazil.; Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Danzmann LC; Lutheran University of Brazil, Porto Alegre, Brazil., Stein R; Post-Graduate Program in Sciences: Cardiology and Cardiovascular Sciences, Porto Alegre, Brazil.; Clinic Hospital of Porto Alegre, Porto Alegre, Brazil.; Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Jazyk: angličtina
Zdroj: Trials [Trials] 2022 Apr 11; Vol. 23 (1), pp. 283. Date of Electronic Publication: 2022 Apr 11.
DOI: 10.1186/s13063-022-06257-1
Abstrakt: Background: Heart failure (HF) with reduced ejection fraction (HFrEF) is a syndrome that leads to fatigue and reduced functional capacity due to disease-related pathophysiological mechanisms. Aerobic exercise (AERO) plays a key role in improving HF outcomes, such as an increase in peak oxygen uptake (VO 2 peak). In addition, HF promotes cell senescence, which involves reducing telomere length. Several studies have shown that patients with a worse prognosis (i.e., reduced VO 2 peak) also have shorter telomeres. However, the effects of AERO on telomere length in patients with HFrEF are still unknown. In an attempt to fill this gap, we designed a study to determine the effects of 16 weeks of aerobic training (32 sessions) on telomere length in HFrEF patients.
Methods: In this single-center randomized controlled trial, men and women between 50 and 80 years old will be allocated into two different groups: a moderate-intensity aerobic training and a control grouTelomere length, functional capacity, echocardiographic variables, endothelial function, and walking ability will be assessed before and after the 16-week intervention period.
Discussion: Understanding the role of physical exercise in biological aging in HFrEF patients is relevant. Due to cell senescence, these individuals have shown a shorter telomere length. AERO can delay biological aging according to a balance in oxidative stress through antioxidant action. Positive telomere length results are expected for the aerobic training group.
Trial Registration: ClinicalTrials.gov NCT03856736 . Registered on February 27, 2019.
(© 2022. The Author(s).)
Databáze: MEDLINE
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