Skin microbiome alters attractiveness to Anopheles mosquitoes.

Autor: Showering A; Department of Disease Control, London School of Hygiene & Tropical Medicine, London, UK. Alicia.showering1@lshtm.ac.uk., Martinez J; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, 464 Bearsden Road, Glasgow, G61 1QH, UK., Benavente ED; Department of Experimental Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands., Gezan SA; VSN International Ltd, Hemel Hempstead, Hertfordshire, UK., Jones RT; Department of Disease Control, London School of Hygiene & Tropical Medicine, London, UK., Oke C; Department of Disease Control, London School of Hygiene & Tropical Medicine, London, UK., Tytheridge S; Department of Disease Control, London School of Hygiene & Tropical Medicine, London, UK., Pretorius E; Department of Disease Control, London School of Hygiene & Tropical Medicine, London, UK., Scott D; Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK., Allen RL; Institute for Infection and Immunity, St George's, University of London, London, UK., D'Alessandro U; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, Gambia., Lindsay SW; Department of Biosciences, University of Durham, Durham, UK., Armour JAL; School of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, UK., Pickett J; School of Chemistry, Cardiff University, Cardiff, Wales, UK., Logan JG; Department of Disease Control, London School of Hygiene & Tropical Medicine, London, UK.
Jazyk: angličtina
Zdroj: BMC microbiology [BMC Microbiol] 2022 Apr 11; Vol. 22 (1), pp. 98. Date of Electronic Publication: 2022 Apr 11.
DOI: 10.1186/s12866-022-02502-4
Abstrakt: Background: Some people produce specific body odours that make them more attractive than others to mosquitoes, and consequently are at higher risk of contracting vector-borne diseases. The skin microbiome can break down carbohydrates, fatty acids and peptides on the skin into volatiles that mosquitoes can differentiate.
Results: Here, we examined how skin microbiome composition of women differs in relation to level of attractiveness to Anopheles coluzzii mosquitoes, to identify volatiles in body odour and metabolic pathways associated with individuals that tend to be poorly-attractive to mosquitoes. We used behavioural assays to measure attractiveness of participants to An. coluzzii mosquitoes, 16S rRNA amplicon sequencing of the bacteria sampled from the skin and gas chromatography of volatiles in body odour. We found differences in skin microbiome composition between the poorly- and highly-attractive groups, particularly eight Amplicon Sequence Variants (ASVs) belonging to the Proteobacteria, Actinobacteria and Firmicutes phyla. Staphylococcus 2 ASVs are four times as abundant in the highly-attractive compared to poorly-attractive group. Associations were found between these ASVs and volatiles known to be attractive to Anopheles mosquitoes. Propanoic pathways are enriched in the poorly-attractive participants compared to those found to be highly-attractive.
Conclusions: Our findings suggest that variation in attractiveness of people to mosquitoes is related to the composition of the skin microbiota, knowledge that could improve odour-baited traps or other next generation vector control tools.
(© 2022. The Author(s).)
Databáze: MEDLINE
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