Cardiopulmonary Rehabilitation in Long-COVID-19 Patients with Persistent Breathlessness and Fatigue: The COVID-Rehab Study.

Autor: Besnier F; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada.; Department of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada., Bérubé B; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada.; Department of Psychology, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada.; Research Center, Institut Universitaire de Gériatrie de Montréal, Montréal, QC H3W 1W5, Canada., Malo J; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada.; Department of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada., Gagnon C; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada., Grégoire CA; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada., Juneau M; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada.; Department of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada., Simard F; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada.; Department of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada., L'Allier P; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada.; Department of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada., Nigam A; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada.; Department of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada., Iglésies-Grau J; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada.; Department of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada., Vincent T; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada., Talamonti D; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada., Dupuy EG; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada.; Department of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada., Mohammadi H; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada., Gayda M; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada.; Department of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada., Bherer L; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada.; Department of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada.; Research Center, Institut Universitaire de Gériatrie de Montréal, Montréal, QC H3W 1W5, Canada.
Jazyk: angličtina
Zdroj: International journal of environmental research and public health [Int J Environ Res Public Health] 2022 Mar 31; Vol. 19 (7). Date of Electronic Publication: 2022 Mar 31.
DOI: 10.3390/ijerph19074133
Abstrakt: (1) Background: Cardiopulmonary and brain functions are frequently impaired after COVID-19 infection. Exercise rehabilitation could have a major impact on the healing process of patients affected by long COVID-19. (2) Methods: The COVID-Rehab study will investigate the effectiveness of an eight-week cardiopulmonary rehabilitation program on cardiorespiratory fitness (V˙O 2 max) in long-COVID-19 individuals. Secondary objectives will include functional capacity, quality of life, perceived stress, sleep quality (questionnaires), respiratory capacity (spirometry test), coagulation, inflammatory and oxidative-stress profile (blood draw), cognition (neuropsychological tests), neurovascular coupling and pulsatility (fNIRS). The COVID-Rehab project was a randomised clinical trial with two intervention arms (1:1 ratio) that will be blindly evaluated. It will recruit a total of 40 individuals: (1) rehabilitation: centre-based exercise-training program (eight weeks, three times per week); (2) control: individuals will have to maintain their daily habits. (3) Conclusions: Currently, there are no specific rehabilitation guidelines for long-COVID-19 patients, but preliminary studies show encouraging results. Clinicaltrials.gov (NCT05035628).
Databáze: MEDLINE
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