Autor: |
Shieu MK; Division of General Practice, Department of Medical Education, Changhua Christian Hospital, Changhua 500, Taiwan., Ho HY; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan., Lin SH; Department of Surgical Pathology, Changhua Christian Hospital, Changhua 500, Taiwan.; Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung 406, Taiwan., Lo YS; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan., Lin CC; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan., Chuang YC; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan., Hsieh MJ; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan., Chen MK; Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua 500, Taiwan. |
Abstrakt: |
Lysine methyltransferase 2C (KMT2C) is a tumor-suppressor gene in several myeloid cells and epithelia and is linked with blood and solid tumor cancers. KMT2C single-nucleotide polymorphisms (SNPs) are also connected with several cancer types. Our study aimed to explore the potential genetic polymorphisms of KMT2C in oral cancer. Five KMT2C SNPs, including rs201834857, rs4725443, rs6464221, rs74483926, and rs6943984, were evaluated in 284 cancer-free controls and 284 oral squamous cell carcinoma (OSCC) cases. We found that individuals with the TC genotype or TC + CC genotype of rs4725443 had a higher risk of oral cancer incidence than those with the TT genotype. Further analysis of KMT2C SNP rs4725443 revealed that the TC + CC genotype of rs4725443 was associated with a significantly advanced tumor stage in the non-alcohol-drinking population. Moreover, the TC + CC genotype of rs4725443 was connected with poor cell differentiation in the alcohol-drinking population. Through analyzing a dataset from The Cancer Genome Atlas (TCGA), we found that reduced KMT2C levels were associated with advanced tumor stage, lymph node invasion, and poor cell differentiation in head and neck squamous cell carcinomas. Our data suggest that KMT2C SNP rs4725443 is a potential genetic marker for oral cancer patients in both non-alcohol-drinking and alcohol-drinking populations. |