| Autor: |
Citu IM; Department of Internal Medicine I, 'Victor Babes' University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania., Citu C; Department of Obstetrics and Gynecology, 'Victor Babes' University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania., Margan MM; Department of Obstetrics and Gynecology, 'Victor Babes' University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania., Craina M; Department of Obstetrics and Gynecology, 'Victor Babes' University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania., Neamtu R; Department of Obstetrics and Gynecology, 'Victor Babes' University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania., Gorun OM; Department of Obstetrics and Gynecology, Municipal Emergency Clinical Hospital Timisoara, 300202 Timisoara, Romania., Burlea B; Department of Obstetrics and Gynecology, Municipal Emergency Clinical Hospital Timisoara, 300202 Timisoara, Romania., Bratosin F; Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania., Rosca O; Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania., Grigoras ML; Department of Anatomy and Embryology, 'Victor Babes' University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania., Motoc A; Department of Anatomy and Embryology, 'Victor Babes' University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania., Malita D; Department of Radiology, 'Victor Babes' University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania., Neagoe O; First Department of Surgery, Second Discipline of Surgical Semiology, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania., Gorun F; Department of Obstetrics and Gynecology, 'Victor Babes' University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania. |
| Abstrakt: |
Magnesium may contribute to the immune response during and after SARS-CoV-2 infection by acting as a cofactor for immunoglobulin production and other processes required for T and B cell activity. Considering magnesium as a recommended dietary supplement during pregnancy and the possible role of magnesium deficiency in COVID-19 and its complications, the current study sought to determine the effect of magnesium and magnesium-containing nutritional supplements on the immune response following SARS-CoV-2 infection in pregnant women, as well as to observe differences in pregnancy outcomes based on the supplements taken during pregnancy. The study followed a cross-sectional design, where patients with a history of SARS-CoV-2 infection during their pregnancy were surveyed for their preferences in nutritional supplementation and their profile compared with existing records from the institutional database. A cohort of 448 pregnant women with COVID-19 during 22 months of the pandemic was assembled, out of which 13.6% took a magnesium-only supplement, and 16.5% supplemented their diet with a combination of calcium, magnesium, and zinc. Around 60% of patients in the no-supplementation group had the SARS-CoV-2 anti-RBD lower than 500 U/mL, compared with 50% in those who took magnesium-based supplements. A quantity of magnesium >450 mg in the taken supplements determined higher levels of antibody titers after COVID-19. Low magnesium dosage (<450 mg) was an independent risk factor for a weak immune response (OR-1.25, p-value = 0.003). The observed findings suggest supplementing the nutritional intake of pregnant women with magnesium-based supplements to determine higher levels of SARS-CoV-2 anti-RBD antibodies, although causality remains unclear. |
